Publications by authors named "Marcos Hernando-Gozalo"
Article Synopsis
- The study investigates the role of Blastocystis subtype diversity in infection outcomes and associated symptoms in 219 patients.
- The most common subtypes identified were ST3 (29.7%) and ST4 (22.8%), with no significant associations found between these subtypes or patient factors (like age or travel history) and gastrointestinal symptoms.
- However, younger age and conditions like skin pruritus and eosinophilia were linked to a higher likelihood of gastrointestinal issues, suggesting that Blastocystis subtype variability is not a primary factor in clinical manifestations.
Gastrointestinal microorganism resistance and dissemination are increasing, partly due to international travel. This study investigated gastrointestinal colonisations and the acquisition of antimicrobial resistance (AMR) genes among international travellers moving between Spain and low- and middle-income countries (Peru and Ethiopia). We analysed 102 stool samples from 51 volunteers collected before and after travel, revealing significantly higher rates of colonisation by both bacteria and protists upon return.
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- The study focuses on the synthesis of five small molecules featuring a guanidine core through guanylation reactions, a key method in medicinal chemistry.
- These compounds were tested against various strains of bacteria, including extended-spectrum beta-lactamase (ESBL) producers and methicillin-resistant Staphylococcus aureus (MRSA), using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests.
- Results indicate that these guanidine-core molecules show potential as new treatments for bacterial infections, especially against drug-resistant strains, suggesting further research is necessary to optimize their effectiveness.
Article Synopsis
- The study aimed to evaluate the clinical outcomes of patients with Clostridioides difficile infection (CDI) based on different antibiotic treatments and to assess antibiotic resistance in a Spanish hospital over one year.
- A total of 194 patients were analyzed, showing that vancomycin and fidaxomicin treatments were linked to longer hospital stays, while fidaxomicin was associated with a higher chance of recurrence (rCDI) compared to metronidazole.
- The resistance rates found were low for both vancomycin and metronidazole, and hypervirulent strains did not show a significant connection to mortality despite higher rates of mortality among those infected.
Study of the antimicrobial activity of cationic carbosilane dendrimers against clinical strains of multidrug-resistant bacteria and their biofilms.
Front Cell Infect Microbiol
October 2023
Article Synopsis
- - Antimicrobial Resistance, worsened by microorganisms forming biofilms, presents a public health threat, prompting the exploration of new treatments like cationic dendritic systems (dendrimers and dendrons).
- - The research tested six cationic carbosilane dendrimers and one dendron against multidrug-resistant bacteria and their biofilms, evaluating their effectiveness through various concentration measurements and assessing cytotoxicity on Hela cells.
- - Results showed that certain dendrimers and the dendron had significant antibacterial activity against resistant bacteria in their planktonic state, but their effectiveness against biofilms was limited, highlighting their potential for topical use against infections.
Article Synopsis
- Low- and middle-income countries, like Ghana, face significant challenges with antimicrobial resistance (AMR) due to limited microbiological studies and surveillance systems.
- A study conducted in 2022 at Saint Dominic's Hospital examined the prevalence of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) bacteria among clinical samples from 2905 patients, revealing that over half of the microorganisms tested showed MDR traits.
- The research identified key risk factors for acquiring MDR/XDR bacteria, highlighting the importance of targeted surveillance, improved diagnostics, and susceptibility testing to tackle the growing issue of AMR.
A limited number of longitudinal studies have examined the symptoms associated with long-COVID-19. We conducted an assessment of symptom onset, severity and patient recovery, and determined the percentage of patients who experienced reinfection up to 2 years after the initial onset of the disease. Our cohort comprises 377 patients (≥18 years) with laboratory-confirmed COVID-19 in a secondary hospital (Madrid, Spain), throughout March 3-16, 2020.
View Article and Find Full Text PDFHelicobacter pylori is a Gram-negative bacterium that causes chronic gastric inflammation, which can lead to gastric neoplasia. Therefore, early diagnosis of H. pylori infection is crucial for effective treatment and prevention of complications.
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