Publications by authors named "Marcos Euzebio Maciel"
MTAP is a ubiquitously expressed gene important for adenine and methionine salvage. The gene is located at 9p21, a chromosome region often deleted in breast carcinomas, similar to CDKN2A, a recognized tumor suppressor gene. Several research groups have shown that MTAP acts as a tumor suppressor, and some therapeutic approaches were proposed based on a tumors´ MTAP status.
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- Individual differences in how people metabolize substances may impact their risk for complex diseases, making genetic studies relevant.
- The research focused on gene families related to metabolism (cytochrome P450 and glutathione S-transferase) and involved 115 Euro-descendants and 196 Afro-descendants in Curitiba, Brazil.
- Findings revealed varying mutation and null genotype frequencies between the two groups for six specific genes, which are important for further understanding genetic susceptibility to diseases.
Oral carcinoma is the sixth most frequent type of cancer in the world and the seventh most common in Brazil (the country with the highest incidence in Latin America). Mean five-year survival remains one of the lowest among the main cancers, thus justifying studies that contribute to the development of preventive strategies. The aim of this study was to compare the epidemiological, clinical, and histological characteristics of 91 patients with oral carcinoma.
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