Publications by authors named "Marcos Casado"
Article Synopsis
- - Excess body fat contributes to the development of colon cancer (CC) by increasing the expression of the pro-inflammatory cytokine IL-1β, which is linked to obesity-related inflammation and tumor growth.
- - A study involving human samples and a rat model showed that obesity and CC both significantly elevate IL-1β levels in adipose tissue and colon, with weight loss leading to a decrease in IL-1β expression.
- - Treating colon cancer cells (HT-29) with IL-1β and substances from obese patients' fat cells promoted inflammatory markers and reduced anti-inflammatory gene expression, highlighting IL-1β's role in driving inflammation linked to obesity and CC.
Background: Obesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading to the development of metabolic diseases. The inflammasomes constitute essential components in the regulation of intestinal homeostasis. We aimed to determine the impact of the inflammasomes in the regulation of gut barrier dysfunction and metabolic inflammation in the context of obesity and type 2 diabetes (T2D).
View Article and Find Full Text PDFBackground: Inflammasomes maintain tissue homeostasis and their altered regulation in the colon, and the adipose tissue (AT) leads to chronic activation of inflammatory pathways promoting colon cancer (CC) development. We aimed to analyze the potential involvement of inflammasomes in obesity-associated CC.
Methods: Ninety-nine volunteers [61 with obesity (OB) and 38 normoponderal (NP)] further subclassified according to the approved protocol for the diagnosis of CC (58 without CC and 41 with CC) were included in the case-control study.