Publications by authors named "Marcos C B Oliveira"
Probable 4-Repeat Tauopathy Criteria Predict Brain Amyloid Negativity, Distinct Clinical Features, and FDG-PET/MRI Neurodegeneneration Patterns in Corticobasal Syndrome.
Mov Disord Clin Pract
March 2024
Article Synopsis
- Corticobasal syndrome (CBS) can be linked to various underlying disorders, including those related to tau proteins, prompting the Movement Disorders Society (MDS) to introduce "probable 4R-tauopathy" to differentiate between similar conditions like progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).* -
- In a study involving 32 CBS patients, those meeting the 4R-tauopathy criteria (CBS-4RT+) were found to have high specificity but lower sensitivity and accuracy in predicting negative amyloid-PET results compared to those who did not meet the criteria (CBS-4RT-).* -
- CBS-4RT+ patients exhibited distinctive clinical traits (
Objective: We investigated ultrasound patterns of muscle involvement in different types of spinal muscular atrophy (SMA) and their correlation with functional status to determine the pattern of muscle compromise in patients with SMA and the potential role of ultrasound to evaluate disease progression.
Methods: We examined muscles (biceps brachii, rectus femoris, diaphragm, intercostals and thoracic multifidus) of 41 patients with SMA (types 1 to 4) and 46 healthy age- and sex-matched control individuals using B-mode ultrasound for gray-scale analysis (GSA), area (biceps brachii and rectus femoris) and diaphragm thickening ratio. Functional scales were applied to patients only.
Article Synopsis
- Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are adult-onset brain disorders related to abnormal tau protein deposition and categorized among atypical parkinsonian syndromes.
- This review summarizes recent findings on PSP and CBD, focusing on emerging clinical concepts, updated diagnostic criteria, and progress in identifying biomarkers.
- Advancements in research have expanded the understanding of PSP and CBD symptoms, leading to better diagnosis and recognition of various clinical manifestations and underlying pathology linked to these conditions.
Article Synopsis
- Corticobasal syndrome (CBS) is a neurological disorder associated with conditions like corticobasal degeneration and Alzheimer's disease, affecting speech and language in various ways.
- In a study with 31 CBS patients, it was found that a significant number experienced aphasia (67.7%) and apraxia (96.8%), showcasing various speech-language deficits.
- The imaging results revealed that patients without amyloid deposits (CBS-A-) had more dysarthria, linked to specific brain area hypometabolism, while also correlating verbal fluency with brain activity in certain temporal gyri.
We studied a subset of patients with autopsy-confirmed multiple system atrophy who presented a clinical picture that closely resembled either Parkinson's disease or progressive supranuclear palsy. These mimics are not captured by the current diagnostic criteria for multiple system atrophy. Among 218 autopsy-proven multiple system atrophy cases reviewed, 177 (81.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICI) are a novel class of antineoplastic treatment that enhances immunity against tumors. They are associated with immune adverse events, and several neurological syndromes have been described, including multiple sclerosis and atypical demyelination. We performed a systematic literature review of case reports with neurological immune adverse events that presented with central nervous system demyelination, up to December 2019.
View Article and Find Full Text PDFBackground: Development of autonomic failure is associated with more rapid disease course and shorter survival in patients with Parkinson's disease and multiple system atrophy. However, autonomic symptoms have not been specifically assessed as a prognostic factor in progressive supranuclear palsy (PSP). We evaluated whether development of autonomic symptoms is associated with disease progression and survival in PSP.
View Article and Find Full Text PDFBackground: Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies.
Case Report: We report the case of a Hispanic 64-year-old woman with cognitive decline and extensive leukoencephalopathy.
Unlabelled: Recent studies have suggested a possible relationship between temporal lobe epilepsy with mesial temporal sclerosis (MTS) and neurocysticercosis (NC). We performed a case-control study to evaluate the association of NC and MTS.
Method: We randomly selected patients with different epilepsy types, including: MTS, primary generalized epilepsy (PGE) and focal symptomatic epilepsy (FSE).
Unlabelled: Rapidly progressive dementia (RPD) is typically defined as a cognitive decline progressing to severe impairment in less than 1-2 years, typically within weeks or months. Accurate and prompt diagnosis is important because many conditions causing RPD are treatable. Neurosarcoidosis is often cited as an unusual reversible cause of RPD.
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