Biocidal Activity of a Nanoemulsion Containing Essential Oil from Resin against (Diptera: Culicidae).

This work aimed to prepare a nanoemulsion containing the essential oil of the resin and evaluate its biocidal activities against the different stages of development of the mosquito. Ovicide, pupicide, adulticide and repellency assays were performed. The main constituents were -cymene (27.

Curine, a bisbenzylisoquinoline alkaloid, blocks L-type Ca²⁺ channels and decreases intracellular Ca²⁺ transients in A7r5 cells.

Curine is a novel bisbenzylisoquinoline alkaloid that has previously been reported as a vasodilator. The underlying mechanism(s) of the vasodilator effect of curine remains to be characterized. In this study, we investigated the cellular mechanism that is responsible for the vasodilator effect of curine in the rat aorta.

(S)-reticuline induces vasorelaxation through the blockade of L-type Ca(2+) channels.

In Brazil, various species of the genus Ocotea are used in folk medicine for treating several diseases. The chemical characterization of this plant showed the presence of alkaloids belonging to the benzyltetrahydroisoquinoline family, the major component of which is (S)-reticuline. The present study investigated whether (S)-reticuline exerts an inhibitory effect on smooth muscle L-type Ca(2+) channels.