Publications by authors named "Marco Zuin"
In the study of coronary artery disease, the mechanisms underlying atherosclerosis initiation and progression or regression remain incompletely understood. Our research conceptualized the cardiovascular system as an integrated network of pumps and pipes, advocating for a paradigm shift from static imaging of coronary stenosis to dynamic assessments of coronary flow. Further review of fluid mechanics highlighted the water hammer phenomenon as a compelling analog for processes in coronary arteries.
View Article and Find Full Text PDFImportance: Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in patients with cancer in the US and worldwide.
Objectives: To assess the trends in PE-related mortality from 2011 to 2020 among US patients with cancer across age, sex, ethnic and racial groups, urbanicity, and regionality.
Design, Setting, And Participants: This cohort study used the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research data system to determine national trends in age-adjusted mortality rates (AAMRs) due to acute PE among US patients with cancer aged 15 years or older from January 2011 to December 2020.
Background: Stroke is a leading cause of death in Vietnam. However, a comprehensive analysis of stroke burden remains limited. This study aims to investigate the burden of stroke and various risk factors in Vietnam from 1990 to 2021.
View Article and Find Full Text PDFAmyloid beta (Aβ) dyshomeostasis is considered the main biological aberration in Alzheimer's Disease (AD) pathology. The interplay between Aβ formation and clearance is predominantly modulated by a disintegrin and a metalloproteinase 10 (ADAM10, α-secretase) and β-site APP Cleaving Enzyme 1 (BACE1), the two pivotal enzymes in both non-amyloidogenic/amyloidogenic and amyloidolytic pathways. Emerging evidence suggests that aberrations in ADAM10 and BACE1 expression, activity, and function in the brain of AD patients also manifest in peripheral fluids, suggesting their potential as blood-based biomarkers for AD diagnosis.
View Article and Find Full Text PDFBackground: Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region.
Methods And Results: Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020.
Aims: The use of ultrasound (US)-guided venous puncture for cardiac pacing/defibrillation lead placement may minimize the risk of periprocedural complications and radiation exposure. However, none of the published studies have been sufficiently powered to recommend this approach as the standard of care. We compare the safety and efficacy of ultrasound-guided axillary venous puncture (US-AVP) vs.
View Article and Find Full Text PDFAlthough anticoagulation remains the cornerstone treatment for patients with acute pulmonary embolism (PE), catheter-directed therapy (CDT) has generated great interest as an adjunctive option for those presenting with hemodynamic decompensation or high risk for deterioration and in whom systemic thrombolysis has failed or is contraindicated. However, randomized controlled data supporting the efficacy and safety of CDT in addition to antithrombotic therapy in patients with high-risk and intermediate- to high-risk PE compared with anticoagulation and systemic thrombolysis alone are lacking. This paucity of high-quality data hampers guideline recommendations regarding the optimal therapeutic approach in such patients with PE.
View Article and Find Full Text PDFRole of PCSK9 inhibitors in venous thromboembolism: current evidence and unmet clinical needs.
Eur Heart J Cardiovasc Pharmacother
January 2025
Article Synopsis
- * Early studies indicate that PCSK9i could help patients who have experienced venous thromboembolism (VTE), with benefits appearing more significant after the first year of treatment.
- * The article reviews current evidence on using PCSK9i alongside standard anticoagulant therapy for VTE risk reduction, highlighting gaps in research and suggesting future strategies to fill these gaps.
Article Synopsis
- Despite advancements in clinical practices, pulmonary embolism (PE) remains a significant challenge in diagnosis and treatment due to factors like aging populations and health disparities.
- Clinicians often rely on various international guidelines for managing PE, but inconsistencies and gaps in recommendations can lead to confusion.
- This review focuses on key similarities and differences in PE guidelines and emphasizes the need for clearer management strategies and further research in this area.
Carina: A major determinant in the pathophysiology and treatment of coronary bifurcation lesions.
Catheter Cardiovasc Interv
December 2024
Article Synopsis
- Research over the past ten years has improved our understanding of coronary bifurcations, which are junctions in blood vessels that can be critical in heart conditions.
- The carina, or the central part of these bifurcations, influences important blood flow patterns and shear stress, which can affect the development of atherosclerosis.
- This review aims to summarize the current knowledge about the role of the carina in coronary bifurcations to help interventional cardiologists develop better treatment approaches.
Article Synopsis
- The study investigates if using algorithms for right ventricular pacing modulation (RVPm) can lower negative health outcomes compared to traditional dual-chamber pacing (DDD) in patients needing anti-bradycardia treatments.
- The analysis, which included eight studies and over 7,200 patients, revealed that RVPm was associated with a reduced risk of persistent atrial fibrillation and cardiovascular hospitalizations, but no significant impact on overall mortality or adverse symptoms was found.
- Overall, RVPm algorithms appear beneficial in minimizing certain health risks, without increasing unwanted side effects, even for patients with higher levels of atrioventricular block.
Article Synopsis
- - The study analyzed trends in pulmonary embolism (PE)-related mortality in patients with concurrent pulmonary hypertension (PH) in the US over the past two decades, especially during the COVID-19 pandemic, using CDC data.
- - It found that the age-adjusted mortality rates for PE/PH increased significantly, particularly among White individuals and those living in rural areas, with a notable rise during the pandemic in older and female patients.
- - Despite advancements in diagnosing PH in acute PE cases, the overall mortality rate for these patients continues to climb, highlighting an ongoing public health concern.
Article Synopsis
- The study of coronary artery disease (CAD) focuses on understanding how plaque forms and develops, which is critical for improving treatment methods.
- Current coronary angiography (CAG) has limitations as it can only provide static images of arterial blockages without revealing the underlying mechanisms or predicting disease progression.
- A modified CAG technique analyzes blood flow patterns using fluid mechanics principles, helping to identify various flow types and their relationship with arterial lesions, paving the way for better treatment options for CAD.
Article Synopsis
- This study investigates the impact of patent foramen ovale (PFO) on mortality and clinical deterioration risk in patients with intermediate-high-risk pulmonary embolism (PE), using data from the Italian Pulmonary Embolism Registry (IPER).
- Out of 450 PE patients analyzed, 15.1% were found to have PFO, which was linked to significantly higher death rates (29.4% vs. 3.1%) and clinical deterioration within 48 hours (38.2% vs. 3.6%).
- The presence of PFO was identified as a strong predictor for both 30-day mortality and increased risk of deterioration, with statistics showing a hazard ratio of
Backgrounds: Effectiveness of patent foramen ovale (PFO) closure on relief of migraine, is still unclear. We sought to analyse the long-term (>10 years) effects of interatrial septal shunt repair on disabling migraine performing a retrospective non-randomised study.
Methods: Clinical records of patients with disabling, medication-refractory migraine and PFO or significant ASD referred to our centre for closure from 2006 to 2018, were analysed.
Article Synopsis
- A systematic review and meta-analysis were conducted to assess changes in cerebral blood flow (CBF) in Alzheimer's disease (AD) patients compared to healthy age-matched controls using transcranial Doppler ultrasound.
- The analysis included 12 studies and showed that AD patients had significantly lower CBF velocity in the middle cerebral artery, with additional findings indicating a correlation between CBF, arterial hypertension, and cognitive performance (MMSE scores).
- The study concludes that cerebrovascular perfusion is significantly impaired in AD patients, suggesting that TCD may be a valuable diagnostic tool for identifying hemodynamic issues in this population.
Optimal hemodynamic parameters for risk stratification in acute pulmonary embolism patients.
J Thromb Thrombolysis
August 2024
Article Synopsis
- Hemodynamic assessment is crucial for early risk stratification in patients with pulmonary embolism (PE), influencing monitoring and treatment strategies.
- Current guidelines mainly emphasize systolic blood pressure (SBP) as a key indicator, but its reliability for detecting hemodynamic instability has been questioned.
- The article reviews existing evidence on SBP, considers additional parameters for assessing hemodynamic stability, and suggests strategies for further research in treating PE.