A cascade of histone modifications induces chromatin condensation in mitosis.

Metaphase chromosomes are visible hallmarks of mitosis, yet our understanding of their structure and of the forces shaping them is rudimentary. Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear. Using genetically encoded ultraviolet light-inducible cross-linkers, we monitored protein-protein interactions with spatiotemporal resolution in living yeast to identify the molecular details of the pathway downstream of H3 S10 phosphorylation.

Motifs in triadic random graphs based on Steiner triple systems.

Conventionally, pairwise relationships between nodes are considered to be the fundamental building blocks of complex networks. However, over the last decade, the overabundance of certain subnetwork patterns, i.e.

Pulsed chaos synchronization in networks with adaptive couplings.

Networks of chaotic units with static couplings can synchronize to a common chaotic trajectory. The effect of dynamic adaptive couplings on the cooperative behavior of chaotic networks is investigated. The couplings adjust to the activities of its two units by two competing mechanisms: An exponential decrease of the coupling strength is compensated for by an increase due to desynchronized activity.

Insertional mutagenesis screening identifies the zinc finger homeodomain 2 (zfh2) gene as a novel factor required for embryonic leg development in Tribolium castaneum.

The genetic control of leg development is well characterized in the fly Drosophila melanogaster. These control mechanisms, however, must differ to some degree between different insect species to account for the morphological diversity of thoracic legs in the insects. The legs of the flour beetle Tribolium castaneum differ from the Drosophila legs in their developmental mode as well as in their specific morphology especially at the larval stage.