Modeling Rare Disease Datasets with ART-DECOR.

This paper presents ongoing work on the modeling of different datasets using the ART-DECOR modeling tool, with a focus on adherence to the FAIR principles (Findable, Accessible, Interoperable, and Reusable). The successful modeling of the French minimal dataset for rare diseases (Set de donnees minimal des maladies rares (SDM-MR.fr)) should provide inspiration for the development of the German minimal dataset for rare diseases (Minimalbasisdatensatz fur Seltene Erkrankungen (MBDS-SE.

Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress.

Background: Panic disorder (PD) has been associated with an altered activity of the hypothalamic-pituitary-adrenal-cortical (HPA) axis. Recent findings from a patient sample with PD with secondary depression on psychotropic medication using salivary cortisol as outcome measure suggest a non-responsiveness of the HPA-axis under acute psychosocial stress. Salivary cortisol does not necessarily reflect the total plasma cortisol due to interfering variables.