Publications by authors named "Marco Rueedi"
Article Synopsis
- This research identifies 290 genetic factors linked to ovarian ageing by analyzing the age at natural menopause in 200,000 European women, highlighting how genetics can influence reproductive lifespan.*
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- The study reveals that these genetic variants are connected to DNA damage response processes that impact ovarian reserve and depletion rates, suggesting potential therapeutic targets.*
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- Manipulating these pathways in experimental models showed promise in boosting fertility and extending reproductive longevity, while also indicating benefits and risks for women's overall health, such as improved bone health but increased cancer risk.*
Article Synopsis
- - The research identifies 389 genetic signals related to the timing of menarche (first menstrual period) in up to 370,000 women, showing how genetics influence this aspect of puberty and link it to adult diseases.
- - Findings indicate that about 7.4% of the population variation in menarche age can be explained by these genetic signals, with a notable enrichment of associated genes in neural tissues.
- - The study suggests that the timing of puberty has causal relationships with certain cancers, independently of factors like body mass index (BMI), highlighting the intricate genetic factors influencing puberty and its long-term health effects.
