BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases.

BCL11b is a transcription regulator and a tumor suppressor involved in lymphomagenesis, central nervous system (CNS) and immune system developments. BCL11b favors persistence of HIV latency and contributes to control cell cycle, differentiation and apoptosis in multiple organisms and cell models. Although BCL11b recruits the non-coding RNA 7SK and epigenetic enzymes to regulate gene expression, BCL11b-associated ribonucleoprotein complexes are unknown.

CLUE: A Fast Parallel Clustering Algorithm for High Granularity Calorimeters in High-Energy Physics.

One of the challenges of high granularity calorimeters, such as that to be built to cover the endcap region in the CMS Phase-2 Upgrade for HL-LHC, is that the large number of channels causes a surge in the computing load when clustering numerous digitized energy deposits (hits) in the reconstruction stage. In this article, we propose a fast and fully parallelizable density-based clustering algorithm, optimized for high-occupancy scenarios, where the number of clusters is much larger than the average number of hits in a cluster. The algorithm uses a grid spatial index for fast querying of neighbors and its timing scales linearly with the number of hits within the range considered.

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.

HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed. The cellular transcription factor KAP1 is known as a potent repressor of gene transcription.

Microglial Cells: The Main HIV-1 Reservoir in the Brain.

Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. Hidden HIV-1 in cellular and anatomic reservoirs is the major hurdle toward a functional cure. Microglial cells, the Central Nervous system (CNS) resident macrophages, are one of the major cellular reservoirs of latent HIV-1.