Publications by authors named "Marco Pinto-Orellana"

Article Synopsis
  • The study introduces s-EPIC, a data-driven method for automated identification of EEG biomarkers, overcoming biases from visual analysis.
  • Retrospective EEG data were analyzed from 20 subjects with Lennox-Gastaut syndrome (LGS) and 20 healthy controls, revealing four novel EEG clusters that indicate potential biomarkers for LGS.
  • The s-EPIC approach enhances the objectivity and reliability of EEG analysis, potentially aiding in the diagnosis and understanding of various neurological conditions.
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Article Synopsis
  • The study focuses on improving the identification of seizure onset zones (SOZ) in patients with refractory epilepsy using a new metric called channel-level connectivity dispersion (CLCD) to analyze brain activity.
  • CLCD measures the variability in synchronization between individual electrodes and aims to identify connections associated with abnormal brain activity linked to SOZ.
  • The method was tested on two datasets of intracranial electroencephalography signals, showing promising results in differentiating SOZ channels from non-SOZ channels based on lower CLCD values.
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Objective: High-frequency oscillations (HFOs) are a promising prognostic biomarker of surgical outcome in patients with epilepsy. Their rates of occurrence and morphology have been studied extensively using recordings from electrodes of various geometries. While electrode size is a potential confounding factor in HFO studies, it has largely been disregarded due to a lack of consistent evidence.

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Gait and balance are an intricate interplay between the brain, nervous system, sensory organs, and musculoskeletal system. They are greatly influenced by the type of footwear, walking patterns, and surface. This exploratory study examines the effects of the Infinity Walk, pronation, and footwear conditions on brain effective connectivity patterns.

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Background: Various interacting and interdependent components comprise complex interventions. These components create difficulty in assessing the true impact of interventions designed to improve patient-centered outcomes. Interrupted time series (ITS) designs borrow from case-crossover designs and serve as quasi-experimental methodology able to retrospectively assess the impact of an intervention while accounting for temporal correlation.

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Sparse time series models have shown promise in estimating contemporaneous and ongoing brain connectivity. This paper was motivated by a neuroscience experiment using EEG signals as the outcome of our established interventional protocol, a new method in neurorehabilitation toward developing a treatment for visual verticality disorder in post-stroke patients. To analyze the [complex outcome measure (EEG)] that reflects neural-network functioning and processing in more specific ways regarding traditional analyses, we make a comparison among sparse time series models (classic VAR, GLASSO, TSCGM, and TSCGM-modified with non-linear and iterative optimizations) combined with a graphical approach, such as a Dynamic Chain Graph Model (DCGM).

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In this article, we consider an emergent problem in the sensor fusion area in which unreliable sensors need to be identified in the absence of the ground truth. We devise a novel solution to the problem using the theory of replicator dynamics that require mild conditions compared to the available state-of-the-art approaches. The solution has a low computational complexity that is linear in terms of the number of involved sensors.

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