Publications by authors named "Marco Milone"

Article Synopsis
  • The study aims to provide updated evidence for managing stage I colon cancer (CC) post-surgery, focusing on recurrence rates and risk factors.
  • Despite low recurrence risk, some guidelines suggest intensive follow-up is unnecessary, but data on actual recurrence rates is limited.
  • The findings reveal a 5% recurrence rate, primarily systemic, with significant risk factors including tumor characteristics and patient demographics, suggesting a need for improved postoperative follow-up strategies.
View Article and Find Full Text PDF

Importance: Evidence suggests that prophylactic abdominal drainage after gastrectomy for cancer may reduce postoperative morbidity and hospital stay but this evidence comes from small studies with a high risk of bias. Further research is needed to determine whether drains safely meet their primary purpose of identifying and managing postoperative intraperitoneal collections without the need for reoperation or additional percutaneous drainage.

Objective: To determine whether avoiding routine abdominal drainage increased postoperative invasive procedures.

View Article and Find Full Text PDF
Article Synopsis
  • This study evaluates the effectiveness of Robot-assisted minimally invasive esophagectomy (RAMIE) for treating esophageal cancer at various centers globally, aiming to pinpoint areas for enhancement in surgical outcomes.
  • Over three time periods (2016-2023), data from 28 centers was analyzed, revealing improvements in textbook outcome rates, lymph node yields, and decreased hospital stays, particularly with McKeown procedures.
  • The results showed varying success rates in surgical outcomes and complications, with a noteworthy decrease in anastomotic leakage rates and hospital stays over time, highlighting advancements in surgical techniques.
View Article and Find Full Text PDF
Article Synopsis
  • * Researchers identified PANDAR, a long non-coding RNA (lncRNA), as significantly up-regulated in APCs of individuals with obesity, particularly those transitioning from normal glucose tolerance to impaired glucose tolerance or T2D.
  • * Silencing PANDAR in senescent APCs appears to reverse senescence and enable cell cycle re-entry, suggesting that targeting PANDAR may offer a new approach to prevent or delay the progression toward T2D in obese patients.
View Article and Find Full Text PDF

: The textbook outcome (TO) is a composite tool introduced to uniform surgical units and regulate surgical quality and outcomes. A patient is considered TO only if all predetermined items are met. In colorectal surgery, TO represents a new tool that can achieve important results given the prevalence of colorectal cancers.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigated the effectiveness of robotic right colectomy (RRC) compared to laparoscopic right colectomy (LRC) for nonmetastatic pT4 colon cancer, focusing on surgical outcomes like cancer removal success, complication rates, and recovery times.
  • - Results showed similar cancer removal rates and lymph node retrieval between RRC and LRC, but RRC had advantages like fewer conversions to open surgery, less blood loss, and fewer postoperative complications.
  • - Both surgical methods had comparable long-term survival rates, indicating that RRC is a viable option for treating pT4 right colon cancer with better short-term results than LRC.
View Article and Find Full Text PDF

Background: As the population ages, more older adults are presenting for surgery. Age-related declines in physiological reserve and functional capacity can result in frailty and poor outcomes after surgery. Hence, optimizing perioperative care in older patients is imperative.

View Article and Find Full Text PDF
Article Synopsis
  • Robotic surgery is becoming popular for planned surgeries, but how it works in emergencies is not well known yet.
  • A new study called the ROEM study will look at how safe and effective robotic surgery is for emergency cases, like when people have serious stomach problems.
  • They will collect information from at least 500 patients across 50 different hospitals to see how well this type of surgery works, while also making sure everything follows ethical rules.
View Article and Find Full Text PDF
Article Synopsis
  • This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
  • Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
  • The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
View Article and Find Full Text PDF

Background: The aim of the present study is to compare outcomes of the robotic hand-sewn, linear- and circular-stapled techniques performed to create an intrathoracic esophagogastric anastomosis in patients who underwent Ivor-Lewis esophagectomy.

Methods: Patients who underwent a planned Ivor-Lewis esophagectomy were retrospectively analysed from prospectively maintained databases. Only patients who underwent a robotic thoracic approach with the creation of an intrathoracic esophagogastric anastomosis were included in the study.

View Article and Find Full Text PDF

Background: The aim of this study was to investigate 8-mm robotic trocar site hernia (TSH) rate over the short and long term, providing aids to manage the related fascial wounds.

Methods: A retrospective analysis of 320 patients undergoing robotic surgery was conducted. The primary outcome was 8-mm TSH rate with a minimum follow-up of 12 months.

View Article and Find Full Text PDF

A novel octaurea-calix[4]tube (UC4T) has been synthesized in three steps from the original Beer's -butylcalix[4]tube ionophore. In a polar solvent (DMSO-), UC4T rapidly interconverts between two identical conformations with symmetry for the two calix[4]arene subunits. However, in a less polar solvent mixture (CDCl/DMSO-, 98 : 2), UC4T adopts a highly distorted asymmetric structure, which hinders the formation of typical tetraurea calix[4]arene capsular assemblies.

View Article and Find Full Text PDF

Deferiprone, generally, is considered an important chelating agent for Fe overload. From a literature data analysis, a lack of information on the interaction of this molecule toward a series of metal cations emerged, inducing to fill out the topic. The complexing ability of deferiprone toward Ca, Mg, Cd and Pb was studied by potentiometry and H NMR spectroscopy, in KCl aqueous solutions at different ionic strength values (0.

View Article and Find Full Text PDF

Abdominal wall hernia repair, a common surgical procedure, includes various techniques to minimize postoperative complications and enhance outcomes. This review focuses on the comparison between laparoscopic and robotic approaches in treating inguinal and ventral hernias, presenting the ongoing situation of this topic. A systematic search identified relevant studies comparing laparoscopic and robotic approaches for inguinal and ventral hernias.

View Article and Find Full Text PDF

Aim: Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal.

Method: A retrospective cohort analysis on patients between 1 January 2010 and 31 December 2020 with a defunctioning stoma for middle and low rectal anterior resection was performed.

View Article and Find Full Text PDF

This article reports on the synthesis of an innovative smart polymer, P5-QPDMAEMA, opportunely developed with the aim of combining the responsiveness of PDMAEMA polymer and the host-guest properties of covalently linked pillar[5]arenes. Thanks to a traditional Non-Induced Phase Separation (NIPS) process performed at various coagulation pH, the blending of P5-QPDMAEMA with polyethersulfone gave rise to the formation of functional beads for the removal of organic dyes in water. Adsorption tests are carried out on all the produced blend-based beads by employing two representative dyes, the cationic methylene blue (MB), and the anionic methyl orange (MO).

View Article and Find Full Text PDF
Article Synopsis
  • Minimally invasive total gastrectomy (MITG) is an important surgical approach for treating gastric cancer, but there is currently no consensus on the best techniques for key processes like lymphadenectomy and anastomosis creation.
  • An international panel of expert surgeons participated in a study using the Delphi method, which involved multiple rounds of voting to establish consensus on the technical steps of MITG, resulting in 41 key statements after three rounds.
  • The consensus findings, showing high internal consistency, aim to improve surgical quality and outcomes for patients undergoing MITG by providing standardized techniques based on expert agreement.
View Article and Find Full Text PDF

Background: This study aimed to assess clinical results in terms of intraoperative outcomes, recovery and recurrence of our robotic technique for the treatment of patients affected by simultaneous inguinal and umbilical hernia, providing technical details to facilitate multiquadrant surgery in robotic hernia repair.

Methods: Data from patients affected by simultaneous primary inguinal and umbilical hernia who underwent robotic repair with our dual docking technique was retrospectively analysed.

Results: Fifteen patients were included.

View Article and Find Full Text PDF

Anastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide "prophylaxis" against AL. However, although in surgical practice it is increasingly used, evidence on humans is still lacking.

View Article and Find Full Text PDF

Background: This study aimed to compare the short- and long-term outcomes of robotic (RRC-IA) versus laparoscopic (LRC-IA) right colectomy with intracorporeal anastomosis using a propensity score matching (PSM) analysis based on a large European multicentric cohort of patients with nonmetastatic right colon cancer.

Methods: Elective curative-intent RRC-IA and LRC-IA performed between 2014 and 2020 were selected from the MERCY Study Group database. The two PSM-groups were compared for operative and postoperative outcomes, and survival rates.

View Article and Find Full Text PDF

Purpose: Several risk factors affecting the adequacy of colon cleansing have been proposed during the last decades. However, less is known about the impact that atmospheric aspects could have on adequacy of the bowel cleansing. The study aimed to investigate if the atmospheric temperature could impact on the bowel cleansing during colonoscopy.

View Article and Find Full Text PDF

Since its inception, robotic surgery has made incredible progress and has undergone significant development in an extremely short period of time [...

View Article and Find Full Text PDF

Achalasia is a rare primary esophageal disorder characterized by impaired functioning of the lower esophageal sphincter. The goal of treatment is to reduce symptoms and improve the quality of life. The gold standard of surgical approach is Heller-Dor myotomy.

View Article and Find Full Text PDF