Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca waves.

We investigated how oxidative stress (OS) alters Ca handling in ventricular myocytes in early metabolic syndrome (MetS) in sucrose-fed rats. The effects of -acetyl cysteine (NAC) or dl-Dithiothreitol (DTT) on systolic Ca transients (SCaTs), diastolic Ca sparks (CaS) and Ca waves (CaW), recorded by confocal techniques, and L-type Ca current (I), assessed by whole-cell patch clamp, were evaluated in MetS and Control cells. MetS myocytes exhibited decreased SCaTs and CaS frequency but unaffected CaW propagation.

The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans.

Chronic exposure to elevated glucose levels leads to fatty acid accumulation, which promotes the development of metabolic diseases such as obesity and type 2 diabetes. MXL-3 is a conserved transcriptional factor that modulates the inhibition of lipolysis in . However, the role of MXL-3 in lipid metabolism during nutrient excess remains unknown.

Experimental hemolysis model to study bilirubin encephalopathy in rat brain.

None of experimental models used to study the toxic effect of unconjugated bilirubin brain accumulation, reproduce the conditions in which the hyperbilirubinemia is a consequence of a hemolytic process, i.e. when important amounts of bilirubin and iron are released.