Publications by authors named "Marco Ludwig"
Article Synopsis
- Most childhood cancers arise randomly without clear inherited causes or lifestyle factors, but certain risk factors may initiate cancer cell transformation.
- The study examined the methylation of intron 2 in 20 childhood cancer patients (both those with a second cancer later and those without) and compared them with cancer-free controls, revealing some elevated methylation levels linked to oncogenic processes.
- Findings suggest that hypermethylation of intron 2 may correlate with genomic changes and cancer progression, indicating its potential role as a biomarker for leukemia and other tumors in children.
We describe monozygotic twins discordant for childhood leukemia and secondary thyroid carcinoma. We used bisulfite pyrosequencing to compare the constitutive promoter methylation of BRCA1 and several other tumor suppressor genes in primary fibroblasts. The affected twin displayed an increased BRCA1 methylation (12%), compared with her sister (3%).
View Article and Find Full Text PDFBackground: The etiology of secondary cancer in childhood cancer survivors is largely unclear. Exposure of normal somatic cells to radiation and/or chemotherapy can damage DNA and if not all DNA lesions are properly fixed, the mis-repair may lead to pathological consequences. It is plausible to assume that genetic differences, i.
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