Impact and applicability of pharmacogenomics in rheumatology: an integrated analysis.

Objectives: Rheumatology medications are often associated with adverse drug reactions (ADRs) or inadequate response (IR). Pharmacogenomics may be a solution, but there is limited knowledge of its potential utility within rheumatology.

Methods: We analysed medication changes and pharmacogenomically actionable prescriptions for all adult rheumatology outpatient encounters at our medical centre between 10/2012-12/2018.

Pulmonary manifestations of systemic lupus erythematosus and Sjögren's syndrome.

Purpose Of Review: Systemic lupus erythematosus (SLE) and Sjögren syndrome are chronic autoimmune inflammatory disorders that can present with multiorgan involvement including the lungs. This review will focus on recent literature pertaining to the epidemiology, pathogenesis, clinical presentation and diagnosis and management of SLE and Sjögren syndrome-associated pulmonary conditions.

Recent Findings: Pulmonary manifestations of both disease entities have been well characterized and lung involvement can be observed during the course of the disease in most cases.

Hospital-acquired infections at an oncological intensive care cancer unit: differences between solid and hematological cancer patients.

Background: Cancer patients have a higher risk of severe sepsis in comparison with non-cancer patients, with an increased risk for hospital-acquired infections (HAI), particularly with multidrug resistant bacteria (MDRB). The aim of the study is to describe the frequency and characteristics of HAI and MDRB in critically ill cancer patients.

Methods: We conducted an 18-month prospective study in patients admitted ≥48 h to an ICU at a cancer referral center in Mexico.