Publications by authors named "Marco Leu"
Article Synopsis
- Articular cartilage has limited regenerative abilities and existing treatments mainly provide temporary pain relief, spurring interest in tissue engineering.
- This study focused on the potential of adipose stromal cells to form spheroids and differentiate into cartilage-like structures for improved cartilage repair.
- Spheroids created using 3D chips showed promising characteristics and maturation, indicating they could be effective in developing cartilage organoids for future clinical applications, including personalized therapies.
Reporter assays are widely used in applications that require measurement of changes in gene expression over time (e.g. drug screening).
View Article and Find Full Text PDFThe mechanisms that regulate the formation of multinucleated muscle fibers from mononucleated myoblasts are not well understood. We show here that extracellular matrix (ECM) receptors of the beta1 integrin family regulate myoblast fusion. beta1-deficient myoblasts adhere to each other, but plasma membrane breakdown is defective.
View Article and Find Full Text PDFNeuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation. Neuromuscular synapses form in the mutant mice, but the synapses are less efficient and contain reduced levels of acetylcholine receptors.
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