Publications by authors named "Marco Kopp"
Background: Bisphosphonates and receptor activator of nuclear factor-kappa B ligand (RANKL)-inhibitors are amongst the bone-modifying agents used as supportive treatment in women with breast cancer who do not have bone metastases. These agents aim to reduce bone loss and the risk of fractures. Bisphosphonates have demonstrated survival benefits, particularly in postmenopausal women.
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- The study investigates the cellular mechanisms behind heat-induced cell death in human fibroblasts, focusing on how extreme temperatures affect these cells over time.
- Researchers found that heating fibroblasts caused about 50% cell death, with a delayed response that peaked around five hours post-exposure, challenging the idea of traditional caspase-mediated apoptosis.
- Instead, the findings suggest a different death mechanism resembling Parthanatos, characterized by increased PARP1 protein levels and translocation of specific factors into the nucleus, indicating a unique response to heat stress rather than typical apoptotic processes.
Background: Systemic corticosteroids are used to treat people with COVID-19 because they counter hyper-inflammation. Existing evidence syntheses suggest a slight benefit on mortality. So far, systemic corticosteroids are one of the few treatment options for COVID-19.
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