Publications by authors named "Marco J Mauritz"
Electroconvulsive Therapy (ECT) is arguably the most effective intervention for treatment-resistant depression. While large interindividual variability exists, a theory capable of explaining individual response to ECT remains elusive. To address this, we posit a quantitative, mechanistic framework of ECT response based on Network Control Theory (NCT).
View Article and Find Full Text PDFArticle Synopsis
- Therapeutic approaches in psychiatry aim to affect the brain's dynamic network transitions, and Network Control Theory helps quantify how one brain region can influence others in this context.
- A study using Diffusion Tensor Imaging data analyzed brain connectivity in 692 major depressive disorder (MDD) patients and 820 healthy controls, revealing differences in network controllability that aren't linked to current symptoms.
- The research found that network controllability in MDD patients is associated with genetic risk factors, family history of mood disorders, and individual characteristics like body mass index, highlighting its potential for personalized mental health treatment strategies.