ChatGPT as a prospective undergraduate and medical school student.

This article reports the results of an experiment conducted with ChatGPT to see how its performance compares to human performance on tests that require specific knowledge and skills, such as university admission tests. We chose a general undergraduate admission test and two tests for admission to biomedical programs: the Scholastic Assessment Test (SAT), the Cambridge BioMedical Admission Test (BMAT), and the Italian Medical School Admission Test (IMSAT). In particular, we looked closely at the difference in performance between ChatGPT-4 and its predecessor, ChatGPT-3.

High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection.

Objectives: No study has evaluated circulating CXCL10 in patients with mixed cryoglobulinemia (MC) and hepatitis C virus (HCV) chronic infection. The aim of this study is to measure inteferon-inducible protein 10 (CXCL10/IP-10), interferon-gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) (Th1 cytokines) in a series of cryoglobulinemic patients and to correlate this parameter to the clinical phenotype.

Methods: Serum CXCL10, IFN-gamma, and TNF-alpha were assayed in 102 patients with hepatitis C-associated cryoglobulinemia (MC + HCV), in 102 sex- and age-matched patients with type C chronic hepatitis without cryoglobulinemia (HCV+), and in 102 sex- and age-matched controls.

B-cells and mixed cryoglobulinemia.

Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process.