Publications by authors named "Marco Dalla Vecchia"
Article Synopsis
- Cell motility is vital for the growth and healing of tissues in multicellular organisms, but excessive movement can contribute to diseases like tumors.
- This review focuses on the regulatory mechanisms that control the spread of neuroblastoma, a pediatric cancer that arises from migratory neural crest cells.
- It highlights the need for new treatments targeting the motility of neuroblastoma cells and the development of standardized methods to evaluate anti-metastatic drugs for better patient outcomes.
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome. A disturbed cell-cell contact that arises when random X-inactivation creates mosaic absence of PCDH19 has been proposed to cause the syndrome.
View Article and Find Full Text PDFBiosensors based on Förster resonance energy transfer (FRET) have revolutionized cellular biology by allowing the direct measurement of biochemical processes . Many genetically encoded sensors make use of fluorescent proteins that are limited in spectral versatility and that allow few ways to change the spectral properties once the construct has been created. In this work, we developed genetically encoded FRET biosensors based on the chemigenetic SNAP and HaloTag domains combined with matching organic fluorophores.
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