Opioid system and related ligands: from the past to future perspectives.

Chronic pain is a pathological condition affecting about 30% of population. It represents a relevant social-health issue worldwide, and it is considered a significant source of human suffering and disability, strongly affecting patients' quality of life. Despite several pharmacological strategies to guarantee an adequate pain management have been proposed over the years, opioids still represent one of the primary choices for treating moderate-to-severe pain in both cancer and non-cancer patients.

Unsupervised Active Visual Search With Monte Carlo Planning Under Uncertain Detections.

We propose a solution for Active Visual Search of objects in an environment, whose 2D floor map is the only known information. Our solution has three key features that make it more plausible and robust to detector failures compared to state-of-the-art methods: i) it is unsupervised as it does not need any training sessions. ii) During the exploration, a probability distribution on the 2D floor map is updated according to an intuitive mechanism, while an improved belief update increases the effectiveness of the agent's exploration.

Leveraging Commonsense for Object Localisation in Partial Scenes.

We propose an end-to-end solution to address the problem of object localisation in partial scenes, where we aim to estimate the position of an object in an unknown area given only a partial 3D scan of the scene. We propose a novel scene representation to facilitate the geometric reasoning, Directed Spatial Commonsense Graph (D-SCG), a spatial scene graph that is enriched with additional concept nodes from a commonsense knowledge base. Specifically, the nodes of D-SCG represent the scene objects and the edges are their relative positions.

Infinite Feature Selection: A Graph-based Feature Filtering Approach.

We propose a filtering feature selection framework that considers subsets of features as paths in a graph, where a node is a feature and an edge indicates pairwise (customizable) relations among features, dealing with relevance and redundancy principles. By two different interpretations (exploiting properties of power series of matrices and relying on Markov chains fundamentals) we can evaluate the values of paths (i.e.

Toward a Wearable System for Predicting Freezing of Gait in People Affected by Parkinson's Disease.

Some wearable solutions exploiting on-body acceleration sensors have been proposed to recognize Freezing of Gait (FoG) in people affected by Parkinson Disease (PD). Once a FoG event is detected, these systems generate a sequence of rhythmic stimuli to allow the patient restarting the gait. While these solutions are effective in detecting FoG events, they are unable to predict FoG to prevent its occurrence.

Forecasting People Trajectories and Head Poses by Jointly Reasoning on Tracklets and Vislets.

In this article, we explore the correlation between people trajectories and their head orientations. We argue that people trajectory and head pose forecasting can be modelled as a joint problem. Recent approaches on trajectory forecasting leverage short-term trajectories (aka tracklets) of pedestrians to predict their future paths.

Evaluating the Group Detection Performance: The GRODE Metrics.

The detection of groups of individuals is attracting the attention of many researchers in diverse fields, from automated surveillance to human-computer interaction, with a growing number of approaches published every year. Unexpectedly, the evaluation metrics for this problem are not consolidated, with some measures inherited from the people detection field, other from clustering, other designed specifically for a particular approach, thus lacking in generalization and making the comparisons between different approaches hard to be carried out. Moreover, most of the existent metrics are scarcely expressive, addressing groups as they are atomic entities, ignoring that they may have different cardinalities, and that group detection approaches may fail in capturing the exact number of individuals that compose it.

Soft Ngram Representation and Modeling for Protein Remote Homology Detection.

Remote homology detection represents a central problem in bioinformatics, where the challenge is to detect functionally related proteins when their sequence similarity is low. Recent solutions employ representations derived from the sequence profile, obtained by replacing each amino acid of the sequence by the corresponding most probable amino acid in the profile. However, the information contained in the profile could be exploited more deeply, provided that there is a representation able to capture and properly model such crucial evolutionary information.

Joint Individual-Group Modeling for Tracking.

We present a novel probabilistic framework that jointly models individuals and groups for tracking. Managing groups is challenging, primarily because of their nonlinear dynamics and complex layout which lead to repeated splitting and merging events. The proposed approach assumes a tight relation of mutual support between the modeling of individuals and groups, promoting the idea that groups are better modeled if individuals are considered and vice versa.

F-formation detection: individuating free-standing conversational groups in images.

Detection of groups of interacting people is a very interesting and useful task in many modern technologies, with application fields spanning from video-surveillance to social robotics. In this paper we first furnish a rigorous definition of group considering the background of the social sciences: this allows us to specify many kinds of group, so far neglected in the Computer Vision literature. On top of this taxonomy we present a detailed state of the art on the group detection algorithms.

Automatic conversational scene analysis in children with Asperger syndrome/high-functioning autism and typically developing peers.

Individuals with Asperger syndrome/High Functioning Autism fail to spontaneously attribute mental states to the self and others, a life-long phenotypic characteristic known as mindblindness. We hypothesized that mindblindness would affect the dynamics of conversational interaction. Using generative models, in particular Gaussian mixture models and observed influence models, conversations were coded as interacting Markov processes, operating on novel speech/silence patterns, termed Steady Conversational Periods (SCPs).

Characterizing humans on Riemannian manifolds.

In surveillance applications, head and body orientation of people is of primary importance for assessing many behavioral traits. Unfortunately, in this context people are often encoded by a few, noisy pixels so that their characterization is difficult. We face this issue, proposing a computational framework which is based on an expressive descriptor, the covariance of features.

Free Energy Score Spaces: Using Generative Information in Discriminative Classifiers.

A score function induced by a generative model of the data can provide a feature vector of a fixed dimension for each data sample. Data samples themselves may be of differing lengths (e.g.

Conversation analysis at work: detection of conflict in competitive discussions through semi-automatic turn-organization analysis.

This study proposes a semi-automatic approach aimed at detecting conflict in conversations. The approach is based on statistical techniques capable of identifying turn-organization regularities associated with conflict. The only manual step of the process is the segmentation of the conversations into turns (time intervals during which only one person talks) and overlapping speech segments (time intervals during which several persons talk at the same time).

Statistical 3D Shape Analysis by Local Generative Descriptors.

In this paper, we propose a new approach for surface representation. Generative models are exploited for encoding the variations of local geometric properties of 3D shapes. Surfaces are locally modeled as a stochastic process which spans a neighborhood area through a set of circular geodesic pathways, captured by a modified version of a Hidden Markov Model (HMM) named multicircular HMM (MC-HMM).

Fully non-homogeneous hidden Markov model double net: a generative model for haplotype reconstruction and block discovery.

Objective: In the last decade, haplotype reconstruction in unrelated individuals and haplotype block discovery have riveted the attention of computer scientists due to the involved strong computational aspects. Such tasks are usually addressed separately, but recently, statistical techniques have permitted them to be solved jointly. Following this trend we propose a generative model that permits researchers to solve the two problems jointly.

Visual MRI: merging information visualization and non-parametric clustering techniques for MRI dataset analysis.

Objective: This paper presents Visual MRI, an innovative tool for the magnetic resonance imaging (MRI) analysis of tumoral tissues. The main goal of the analysis is to separate each magnetic resonance image in meaningful clusters, highlighting zones which are more probably related with the cancer evolution. Such non-invasive analysis serves to address novel cancer treatments, resulting in a less destabilizing and more effective type of therapy than the chemotherapy-based ones.