Observational study on the effectiveness and safety of multiple regimens of triclabendazole in human fascioliasis after failure to standard-of-care regimens.

Objectives: Triclabendazole (TCBZ) is the recommended anthelmintic against Fasciola hepatica at a dose of 10 mg/kg body weight administered as a single or double dose. However, treatment failures to TCBZ standard-of-care (SOC) doses have been reported in humans. The aim of this study was to describe the effectiveness and tolerability of alternative TCBZ regimens in those patients who failed the SOC regimen for fascioliasis in Peru.

C-arm as intraoperative control in reduction of isolated zygomatic arch fractures: a randomized clinical trial.

Purpose: Isolated zygomatic arch fractures (IZAFs) are habitually reduced at a distance, via a temporal approach. Open reductions are not recommended due to the associated morbidity and complications. However, performing closed reductions makes it difficult to determine whether it was done satisfactorily.

Differences in prevalence of geohelminth infections between indigenous and settler populations in a remote Amazonian region of Peru.

Objective: To compare prevalences of intestinal helminths and waterborne protozoa in indigenous and settler populations in a remote area of Peru. These populations live in adjacent but segregated small urban villages.

Methods: Stool samples were collected from representative members of these two populations and analysed for geohelminths and protozoa.

Diagnosis of soil-transmitted helminthiasis in an Amazonic community of Peru using multiple diagnostic techniques.

An observational descriptive study was conducted in a Shipibo-Conibo/Ese'Eja community of the rainforest in Peru to compare the Kato-Katz method and the spontaneous sedimentation in tube technique (SSTT) for the diagnosis of intestinal parasites as well as to report the prevalence of soil-transmitted helminth (STH) infections in this area. A total of 73 stool samples were collected and analysed by several parasitological techniques, including Kato-Katz, SSTT, modified Baermann technique (MBT), agar plate culture, Harada-Mori culture and the direct smear examination. Kato-Katz and SSTT had the same rate of detection for Ascaris lumbricoides (5%), Trichuris trichiura (5%), hookworm (14%) and Hymenolepis nana (26%).

Highly effective and inexpensive parasitological technique for diagnosis of intestinal parasites in developing countries: spontaneous sedimentation technique in tube.

Millions of low-income people in the world are affected by intestinal parasites. Inexpensive, simple, and effective techniques for diagnosis are necessary. The spontaneous sedimentation technique in tube (SSTT), for application in poor healthcare settings and under field-work conditions, was described 25 years ago in Peru by Tello.

Update on strongyloidiasis in the immunocompromised host.

Immunocompromised persons are the most vulnerable population at risk for developing life-threatening clinical syndromes associated with strongyloidiasis, such as hyperinfection syndrome (HS) or dissemination. This review focuses on describing Strongyloides infection in the immunocompromised host, including immune response against this infection, analyzing the cases with HS published during the past 4 years in the United States, and describing the most sensitive diagnostic tools and the most effective treatment for each clinical syndrome. Strongyloidiasis is becoming an important parasitic disease in the United States, especially in the immunocompromised immigrant population.

[Spontaneous sedimentation in tube technique (SSTT) for diagnosis of intestinal parasites].

Objective: The objective of this study was to evaluate the diagnostic efficacy of the Spontaneous Sedimentation in Tube Technique (SSTT) described by Tello, in comparison with the direct smear and other concentration techniques, when it is used to determine the prevalence of intestinal parasites in field and laboratory studies in rural areas of the Andean Region.

Methods: A prospective study (2000-2004) was carried out including 1 802 fecal samples from several areas around Peru: Iquitos (N = 74), Puno (N = 399), Junín (N = 1241), Lima (N = 88).

Results: SSTT showed more sensitivity to detect helminthes and protozoa in comparison to other conventional techniques carried out simultaneously (P;0.

Molecular diagnosis of Strongyloides stercoralis in faecal samples using real-time PCR.

A real-time PCR method targeting the small subunit of the rRNA gene was developed for the detection of Strongyloides stercoralis DNA in faecal samples, including an internal control to detect inhibition of the amplification process. The assay was performed on a range of well-defined control samples (n=145), known positive faecal samples (n=38) and faecal samples from a region in northern Ghana where S. stercoralis infections are highly endemic (n=212), and achieved 100% specificity and high sensitivity.

Use of ivermectin to treat an institutional outbreak of scabies in a low-resource setting.

In a limited-resource hospital in Lima, Peru, 23 (63.9%) of 36 healthcare workers developed pruritus and/or skin lesions after contact with a patient with classic scabies. Of these 23, a total of 5 healthcare workers had scabies confirmed by microscopy.

[Hyperendemic and mesoendemic zones of Fasciola infection surrounding urban Lima : an emerging disease?].

Introduction: The infection caused by F. hepatica is endemic in Perú with an increasing number of endemic areas, the reporting of them is essential to know the impact of the infection in the population.

Objective: To report the prevalence rate of fascioliasis in areas where it had not been detected human cases previously.

[Thiabendazole for the control of Strongyloides stercoralis infection in a hyperendemic area in Peru].

Strongyloides stercoralis infection is a disease caused by an intestinal parasite. This helminth is highly prevalent in tropical and subtropical areas. The preferred treatment is ivermectin, and thiabendazole as a second option available in certain Peruvian institutions.