Combined chemotherapy regimen of carboplatin and paclitaxel as adjuvant treatment for papillary serous and clear cell endometrial cancer.

Objective: Uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCCC) are highly aggressive variants of endometrial cancer. The optimal adjuvant regimen for these uterine malignant types has not yet been defined. The objective of this study was to evaluate the efficacy and toxicity of a combined chemotherapy regimen of carboplatin and paclitaxel as adjuvant treatment for patients with UPSC and UCCC variants.

Successful carboplatin desensitization in patients with proven carboplatin allergy.

Background: Carboplatin is one of the most useful and well tolerated cytotoxic drugs for gynecologic malignancies. Hypersensitivity to carboplatin is not rare among patients receiving multiple recurrent treatments with this drug. The aim of the current study was to offer a safe and convenient carboplatin desensitization strategy to patients with a proven allergic reaction to this drug.

A comparison between different postoperative treatment modalities of uterine carcinosarcoma.

Objective: Uterine carcinosarcomas are highly aggressive neoplasms with no established effective adjuvant therapy. The aim of the present study was to compare between the outcome in three medical institutions in each of which a different postoperative treatment modality was preferred, namely, chemotherapy in one, whole pelvic irradiation (WPI) in another, and sequential treatment (i.e.

Uterine sarcomas versus leiomyomas: gray-scale and Doppler sonographic findings.

Purpose: The aim of the study was to evaluate the contribution of gray-scale sonography and Doppler flow studies in differentiating between uterine sarcomas of different histologic types and leiomyomas.

Patients And Methods: The study included 111 patients, divided retrospectively into 2 groups: 98 patients with leiomyomas and 13 with postoperative diagnosis of uterine sarcoma. This latter group was further divided into a group of 6 patients with uterine leiomyosarcoma and 7 with malignant mixed mesodermal tumor.

Combination of endometrial thickness and time since menopause in predicting endometrial cancer in women with postmenopausal bleeding.

Purpose: This study was conducted to assess the combination of endometrial thickness, as measured by transvaginal sonography, and time since menopause, in predicting the presence of endometrial cancer in women with postmenopausal bleeding.

Methods: The study group consisted of 95 women with postmenopausal bleeding who underwent sonographic measurement of endometrial thickness followed by endometrial biopsy. No patient had ever received hormone replacement therapy.

Inflammatory skin metastases from ovarian carcinoma--a case report and review of the literature.

Background: Skin metastases from ovarian carcinoma are rarely reported. Most cases present as cutaneous nodules, generally as periumbilical Sister Joseph's nodules. An uncommon presentation of cutaneous metastases from ovarian epithelial carcinoma is the inflammatory pattern, which mimics herpetiform lesions to the skin.

Detection of tumor circulating cells by cytokeratin-20 in the blood of patients with granulosa cell tumors.

Objective: Cytokeratins (CKs) are constituents of the intermediate filaments of epithelial cells which are expressed in various combinations, depending on the epithelial type and the degree of differentiation. Using the reverse transcriptase-polymerase chain reaction (RT-PCR) technique, we recently demonstrated that cytokeratin-20 (CK-20), the most recently discovered cytokeratin, is expressed in endometrial carcinoma tumors, in blood, and in lymph nodes with micrometastases of patients treated for endometrial carcinomas. However, CK-20 expression could not be demonstrated in the endometrium of patients with benign diseases, in peripheral blood, in lymph nodes of healthy subjects, or in normal blood cells.

Age contrasts in clinical characteristics and pattern of care in patients with epithelial ovarian cancer.

Objective: The objective of this study was to document and highlight aspects of ovarian cancer treatment that pertain, especially, to elderly women.

Methods: Data were collected retrospectively from all epithelial ovarian cancer patients who were diagnosed in the Gynecologic Oncology Unit at Meir Hospital, Kfar-Saba, Israel, from January 1994 to December 1998.

Results: The study group comprised 143 patients (<70 years n = 97, > or =70 years n = 46).

Papillary serous carcinoma of the peritoneum coexisting with or after endometrial carcinoma.

Objective: Papillary serous carcinoma of the peritoneum (PSCP) coexisting with, or after, endometrial carcinoma (EC) is an extremely rare condition with no documented patient series. The aim of this investigation was to describe our experience in treating five patients diagnosed with PSCP synchronously with EC and two others who developed PSCP metachronously after EC.

Methods: In this retrospective study, we reviewed and analyzed the clinical and pathological data of seven patients diagnosed and managed over a 10-year period.