Effects of amidine derivatives on parasite-macrophage interaction and evaluation of toxicity.

In this work, the effect of amidine derivatives (with bromine and methoxy as substituents) in the "in vitro" parasite-macrophage interaction was evaluated. The potential toxicity was also analyzed. The results show that the methoxy-derivative was able to decrease the percentage of "in vitro" infection, being not hazardous to the host cell.