Publications by authors named "Marco A Rocha-Loures"
Article Synopsis
- Ankylosing spondylitis (AS) is an autoimmune disease primarily targeting axial and sacroiliac joints, influenced by specific SNPs related to cytokine production.
- A study examined the -1082 A>G SNP and serum cytokine levels in 149 AS patients and 169 controls from Brazil, revealing a higher frequency of the G allele in AS patients and significant differences in genotype frequencies.
- Results indicated that patients with the G genotype were three times more likely to develop AS, and elevated serum IL-10 levels were found in AS patients compared to controls.
is an important marker for spondyloarthritis (SpA), however, many SpA patients are negative. Thus, the aim of this study was to investigate the influence of , and gene polymorphisms in SpA patients who were negative. This case-control study was conducted in 158 patients [102 patients with ankylosing spondylitis (AS) and 56 with psoriatic arthritis (PsA)] and 184 controls.
View Article and Find Full Text PDFSpondyloarthritis (SpA) is an inflammatory rheumatic disease related to low bone mineral density. Because vitamin D plays an important role in bone metabolism and immune system modulation, the aim of this study was to evaluate the influence of polymorphisms in vitamin D receptor genes () in the development of SpA. In this case-control study, a total of 244 patients with SpA and 197 individuals with no SpA were included.
View Article and Find Full Text PDFObjectives: HLA-B27 is strongly associated with ankylosing spondylitis (AS) and its presence helps to confirm AS diagnosis. Due to the high HLA polymorphism and the differentiated contribution of alleles and molecules encoded by them, HLA-B*27 allele identification is relevant in the clinical follow-up, diagnosis, and treatment of this spondyloarthropathy. Inexpensive genotyping techniques with high specificity and sensitivity are of great interest in histocompatibility laboratories.
View Article and Find Full Text PDFIntroduction: Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. Polymorphisms in genes that lead to changes in these receptors or that interfere with the transcription rates of mRNA TLR may be involved in the chronic inflammatory immune response observed in SpA.
View Article and Find Full Text PDFBackground And Objectives: Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of and genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in a mixed Brazilian population.
Methods: Genotyping of -308 (rs1800629), -238 (rs361525), (rs2275913), (rs763780), and polymorphisms was performed in 243 patients with SpA and 210 controls from Southern Brazil using SSOP-Luminex (One Lambda) and PCR-SSP assays.