Publications by authors named "Marco A Pizzolato"
Background: To establish stringent complete remission (SCR) in patients with multiple myeloma (MM), it is currently recommended to obtain a normal serum free light chains (sFLC) ratio. The appearance of serum oligoclonal bands (OB) after autologous stem cell transplantation (ASCT) is considered a favorable prognostic factor. The objective of this study was to examine sFLC for assessing SCR in patients with MM, and ASCT with OB.
View Article and Find Full Text PDFOligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: a 16-year experience.
Mariel Emilce Alejandre Leticia Bibiana Madalena Miguel Arturo Pavlovsky Maria Laura Facio Claudia Corrado Marco Antonio Pizzolato
Clin Chem Lab Med
May 2010
Article Synopsis
- The study analyzes 238 multiple myeloma patients who underwent autologous stem cell transplantation (ASCT) to assess tumor response and survival over 16 years.
- Eight patients experienced a transient monoclonal protein band change, while 37 developed oligoclonal bands (OB), which were linked to improved survival rates.
- The presence of OB post-transplant may serve as a positive prognostic indicator, highlighting the need for ongoing monitoring of protein levels in serum and urine for effective treatment evaluation.