The effect of PHAR-DBH-Me, a cannabinoid receptor agonist, on different cardiovascular responses in adult male rats was analyzed. The blood pressure was measured directly and indirectly. The coronary flow was measured by Langendorff preparation, and vasomotor responses induced by PHAR-DBH-Me in aortic rings precontracted with phenylephrine (PHEN) were analyzed.
View Article and Find Full Text PDFCardiovascular effects of endocannabinoids (eCBs) have generated considerable interest since it has been suggested that the eCB system could become the new pharmacological target, either by blocking its activity or by promoting its effects on several cardiovascular diseases such as hypovolemic and septic shock or hypertension. The purpose of this study was to examine the effects of oleamide on several vasomotor responses in adult rats. Blood pressure (BP) was measured both directly and indirectly.
View Article and Find Full Text PDFPrevious studies demonstrated modifications of high-density lipoproteins (HDL) structure and apolipoprotein (apo) A-I catabolism induced by the atorvastatin and fenofibrate combination. However, it remains unknown whether such structural and metabolic changes of HDL were related to an improvement of the HDL-cholesteryl esters (HDL-CE) metabolism. Therefore, we determined the structure of HDL and performed kinetic studies of HDL-CE radiolabeled with tritium in rabbits treated with atorvastatin, fenofibrate, and a combination of both drugs.
View Article and Find Full Text PDFMar Drugs
May 2019
Low-fat diets, lipid-modifying nutraceuticals and a higher level of physical activity are often recommended to reduce dyslipidemia. A double-blind, randomized, crossover, controlled trial was designed to evaluate the independent and synergistic effects of () supplementation (4.5 g·day) with or without performing a physical exercise program (: aerobic exercise (3 days·week) + high-intensity interval training (2 days·week)) on blood lipids and BMI of 52 sedentary men with excess body weight.
View Article and Find Full Text PDFBackground And Aims: There is a close relationship between psychosocial stress and the development of cardiovascular diseases. It has been reported that there are different alterations in endothelial function in this relationship. However, results obtained in different experimental stress models are controversial.
View Article and Find Full Text PDFBackground: The use of glutamine and arginine has shown several advantages in postoperative outcomes in patients after gastrointestinal surgery. We determined the effects of its use in patients with enterocutaneous fistula after operative treatment.
Patients And Methods: Forty patients with enterocutaneous fistula were randomly assigned to one of two groups.
Mar Drugs
December 2018
(1) Background: () has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.
View Article and Find Full Text PDFMar Drugs
October 2018
Unlabelled: Excess weight and obesity are major risk factors for many chronic diseases, and weight-loss interventions often include systematic exercise and nutritional supplements. The purpose of this study was to determine the independent/synergistic effects of supplementation (six weeks, 4.5 g·day) and a systematic physical exercise program (six weeks, twice weekly) on the body composition and cardiorespiratory fitness of overweight and obese subjects.
View Article and Find Full Text PDFBackground: Exposure to electromagnetic fields can affect human health, damaging tissues and cell homeostasis. Stress modulates neuronal responses and composition of brain lipids. The aim of this study was to evaluate the effects of chronic extremely low frequency electromagnetic field (ELF-EMF) exposure, restraint stress (RS) or both (RS + ELF-EMF) on lipid profile and lipid peroxidation in Wistar rat brain.
View Article and Find Full Text PDFBMJ Open
June 2017
Introduction: In order to reduce cardiovascular disease risk factors, a healthy diet must include dietary antioxidants from different sources (eg, ) and regular practice of exercise should be promoted. There is some evidence from animal studies that and exercise decrease cardiovascular disease risks factors. However, very few studies have proved the independent or synergistic effect of plus exercise in humans.
View Article and Find Full Text PDFIn many organisms, the growth under nitrogen-deprivation or a poor nitrogen source impacts on the carbon flow distribution and causes accumulation of neutral lipids, which are stored as lipid droplets (LDs). Efforts are in progress to find the mechanism of LDs synthesis and degradation, and new organisms capable of accumulating large amounts of lipids for biotechnological applications. In this context, when Ustilago maydis was cultured in the absence of a nitrogen source, there was a large accumulation of lipid bodies containing mainly triacylglycerols.
View Article and Find Full Text PDFBackground: Postprandial triglyceridemia may transitory affect the structure of HDL subclasses and probably their antiatherogenic properties but little is known in this field. We analyzed the HDL subclasses lipid content along postprandial period.
Methods: Fifteen metabolic syndrome (MS) patients and 15 healthy controls were enrolled.
Several chronic transmissible (e.g. AIDS) and non transmissible diseases like cadiovascular disease, are associated with oxidative stress (EOX) and dyslipidemia.
View Article and Find Full Text PDFBackground: End-ileostomy or colostomies are constructed for source control in patients with severe abdominal sepsis. After takedown, enterocutaneous fistula represents one of the most feared complications.
Methods: A prospective base was created with all patients that underwent, during a 90 month period, end-ileostomy or colostomy takedown after abdominal sepsis.
Introduction: There is scarce and inconsistent information about gender-related differences in the hydration of sports persons, as well as about the effects of hydration on performance, especially during indoor sports.
Objective: To determine the physiological differences between genders during in indoor physical exercise, with and without hydration.
Methods: 21 spinning sportspeople (12 men and 9 women) participated in three controlled, randomly assigned and non-sequential hydration protocols, including no fluid intake and hydration with plain water or a sports drink (volume adjusted to each individual every 15 min), during 90 min of spinning exercise.
Lipids Health Dis
January 2014
Background: The aim of this study was to evaluate the actions of coenzyme Q10 (CoQ10) on rats with a cholesterol-rich diet (HD) and high doses of atorvastatin (ATV, 0.2, 0.56 or 1.
View Article and Find Full Text PDFRev Med Inst Mex Seguro Soc
November 2013
Background: elementary school students usually stay in school 4.5 hours a day in Mexico. The main food consumption is outside school.
View Article and Find Full Text PDFBackground: elementary school children spend little time at the school in Mexico. The aim was to investigate the activities after school time in children and to determine the presence of overweight and obesity.
Methods: one hundred and seventy two children of both sexes were included.
Trained people exhibit low plasma concentrations of triacylglcyerols in both fasting and postprandial states. Exercise practice is commonly believed to improve postprandial lipemia. In addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity.
View Article and Find Full Text PDFBackground And Aims: It is generally accepted that electromagnetic fields (EMF) can exert biological effects; however, the mechanisms by which EMF elicits responses are still unknown. The present study was designed to assess the immediate effects of acute EMF exposure, movement restriction, and the combination of both on the antioxidant systems and lipid content in the whole brain of rat.
Methods: Thirty two male Wistar rats were arranged in four groups: control, EMF exposed, movement restrained (MR), and EMF + MR for 2 h.
Many enterocutaneous fistulas (ECF) require operative treatment. Despite recent advances, rates of recurrence have not changed substantially. This study aims to determine factors associated with recurrence and mortality in patients submitted to surgical repair of ECF.
View Article and Find Full Text PDFInt J Radiat Biol
December 2010
Purpose: The aim of the present study was to evaluate the early effects of acute (2 h) exposure to extremely low frequency electromagnetic fields (ELF-EMF), as well as movement restraint (MR) and the combination of both on the antioxidant systems in the plasma, liver, kidney, and heart of rats.
Materials And Methods: Twenty-four adult male Wistar rats were divided in two groups, restrained and unrestrained. The restrained animals were confined into an acrylic tube for 120 min.
Introduction: Non-alcoholic fatty liver diseases range from simple steatosis to non-alcoholic steatohepatitis. The "two hits" hypothesis is widely accepted for its pathogenesis: the first hit is an increased fat flux to the liver, which predisposes our patient to a second hit where increasing free fatty acid oxidation into the mitochondria leads to oxidative stress, lipoperoxidation and a chain reaction with increased ROS. Clinical indications include abdominal cramps, meteorism and fatigue.
View Article and Find Full Text PDFBackground: Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats.
View Article and Find Full Text PDFBackground: Hatha Yoga (HY) can be an alternative to improve physical activity in middle-aged and older women. However, conventional HY (CHY) exercising may not result in enough training stimulus to improve cardiovascular fitness. The purpose of this study was to evaluate the effect of an intensive HY intervention (IHY) on cardiovascular risk factors in middle-aged and older women from Northern Mexico.
View Article and Find Full Text PDF