Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine.

Unlabelled: The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2.

Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC ) and those treated with a cannabinoid (MAC ). The effects of morphine (MAC ) and dexmedetomidine (MAC ) on untreated rats and rats treated for 21 days with the cannabinoids (MAC ) and (MAC ) were also studied.

Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2.

Unlabelled: The minimum alveolar concentration MAC of isoflurane was measured in rats chronically treated with WIN 55,212-2.

Methods: The MAC of isoflurane was determined in 24 male rats from expiratory samples at time of tail clamping under the following conditions: without treatment MAC(), in rats treated for 21 days with WIN 55,212-2 MAC(), and in rats 8 days after stopping treatment with WIN 55,212-2 (MAC).

Results: The MAC() was 1.

Molecular iodine/doxorubicin neoadjuvant treatment impair invasive capacity and attenuate side effect in canine mammary cancer.

Background: Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I) exerts antineoplastic effects on different cancer cells activating re-differentiation pathways. In co-administration with anthracyclines, I impairs chemoresistance installation and prevents the severity of side effects generated by these antineoplastic drugs.

Synergistic effect of the interaction between curcumin and diclofenac on the formalin test in rats.

The association of non-steroidal anti-inflammatory drugs with certain plant extracts can increase antinociceptive activity, permitting the use of lower doses and thus limiting side effects. Therefore, the aim objective of the current study was to examine the effects of curcumin on the nociception and pharmacokinetics of diclofenac in rats. Antinociception was assessed using the formalin test.

Evidence for the Participation of ATP-sensitive Potassium Channels in the Antinociceptive Effect of Curcumin.

Background: It has been reported that curcumin, the main active compound of Curcuma longa, also known as turmeric, exhibits antinociceptive properties. The aim of this study was to examine the participation of ATP-sensitive potassium channels (K(ATP) channels) and, in particular, that of the L-arginine-nitric oxide-cyclic GMP-K(ATP) channel pathway, in the antinociceptive effect of curcumin.

Methods: Pain was induced by the intraplantar injection of 1% formalin in the right hind paw of Wistar rats.