Publications by authors named "Marcio-Ajudarte Lopes"

Hemangiomas are benign vascular tumors that are relatively unusual in the oral cavity. The management of labial hemangiomas may be challenging for functional and esthetic reasons. In the present case, a 12-year-old boy with a large congenital hemangioma in the area of the upper lip was referred due to esthetic concerns and a history of treatment failure.

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Unlabelled: Paracoccidioidomycosis (PCM) is a deep systemic mycosis caused by Paracoccidioides brasiliensis. PCM affects predominantly men in their fifth and sixth decades of life, with low prevalence in women. The reasons for this discrepancy are not fully understood, but oestrogen may influence the transformation of the fungus and modulate the immune response.

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Introduction: This longitudinal study assessed the salivary metabolic profile in patients with head and neck cancer (HNC) treated with radiotherapy (RT). This study aims to investigate salivary metabolites and biological oral pathways induced by RT.

Methods: Clinical data and unstimulated whole-mouth saliva (USWMS) were obtained from 45 HNC patients before, during, and one week after the RT.

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Objective: The objective of this study was to explore the clinical and microscopic findings of mandibular buccal bifurcation cysts (MBBCs) in an original case series and to perform a literature review of this lesion.

Study Design: Paraffin-embedded tissue blocks from patients microscopically diagnosed with MBBCs were retrieved from 4 oral and maxillofacial pathology archives. Data, including clinical, radiographic, and microscopic characteristics, treatments used, and follow-up status, were collected from the pathology records.

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Objective: To elucidate the histopathological, immunohistochemical, and ultrastructural characteristics of a large series of calcifying odontogenic cysts (COCs).

Study Design: This was a multicenter cross-sectional retrospective study of seven oral pathology department laboratories from four countries. Clinical, demographic, and radiographic data of the patients were collected.

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Background: The lack of standardized performance assessment metrics and the inconsistent reporting of results can lead to the presentation of overly optimistic outcomes that fail to accurately represent key aspects of the Machine Learning framework and may not align with real-world clinical needs.

Methods: This conceptual review of the literature compiled the theoretical basis for performance analysis of binary and multiclass models.

Results: Accuracy and error rates are straightforward but not ideal if dataset is imbalanced.

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Background: Machine learning techniques hold significant potential to support the diagnosis and prognosis of diseases. However, the success of these approaches is heavily dependent on rigorous data acquisition, preprocessing and data organization.

Methods: This article reviews the literature to evaluate key factors in dataset construction, focusing on data structure, preprocessing, and data organization, particularly in the context of imaging data.

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Objective: The aim of this study was to provide a comprehensive clinicopathological analysis of oral Kaposi sarcoma (KS) cases and examine its relationship with HIV-related immunosuppression.

Study Design: Paraffin-embedded tissue blocks of patients microscopically diagnosed with oral KS were retrieved from three oral and maxillofacial pathology files. Data including clinical, laboratory, microscopic and immunohistochemical findings and treatment employed were retrieved.

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The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.

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Objective: This study aims to provide a literature review of FNAC-diagnosed plasmablastic lymphoma (PBL) cases and present a case of PBL in an HIV patient diagnosed by FNAC.

Methods: A literature review was conducted across eight databases to compile information on FNAC-diagnosed PBL cases without restricting the site of involvement.

Results: The literature review included 23 PBL, with 13 (56.

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Objective: This study aimed to implement and evaluate a Deep Convolutional Neural Network for classifying myofibroblastic lesions into benign and malignant categories based on patch-based images.

Methods: A Residual Neural Network (ResNet50) model, pre-trained with weights from ImageNet, was fine-tuned to classify a cohort of 20 patients (11 benign and 9 malignant cases). Following annotation of tumor regions, the whole-slide images (WSIs) were fragmented into smaller patches (224 × 224 pixels).

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Aims: To develop a model capable of distinguishing carcinoma ex-pleomorphic adenoma from pleomorphic adenoma using a convolutional neural network architecture.

Methods And Results: A cohort of 83 Brazilian patients, divided into carcinoma ex-pleomorphic adenoma (n = 42) and pleomorphic adenoma (n = 41), was used for training a convolutional neural network. The whole-slide images were annotated and fragmented into 743 869 (carcinoma ex-pleomorphic adenomas) and 211 714 (pleomorphic adenomas) patches, measuring 224 × 224 pixels.

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The study of notable people as advocates for raising cancer awareness began in the latter decades of the 20th century. This research aimed to identify Pan-American notable people with head and neck cancer (HNC) and to explore senior health professionals' perspectives on communicating stories of notable patients with HNC to promote prevention. A cross-sectional survey was conducted using an online questionnaire designed in REDCap and administered to 32 senior health professionals with long-standing academic and clinical backgrounds in HNC.

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Article Synopsis
  • The study analyzes the characteristics of oral reactions to injectable soft tissue fillers, focusing on 151 patients, predominantly females averaging 54.9 years old.
  • Most reactions occurred about 20.4 months after injection, often presenting as painless nodules in the lips, with silicone and polymethylmetacrylate being the most common fillers used.
  • Key findings showed differences in reaction patterns based on the type of filler and highlighted the importance for clinicians to recognize these potential reactions when assessing asymptomatic nodules in older female patients.
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Objectives: To describe the historical evolution and dissemination of the Oral Medicine and Oral and Maxillofacial Pathology international societies and associations across the globe, and to provide insights into their significant contributions toward oral health promotion.

Study Design: This review was conducted in accordance with the JBI Scoping Review Methodology Group guidance. The reporting followed the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR).

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Article Synopsis
  • - A retrospective study was conducted to analyze 10 new cases of canalicular adenoma (CAD), reviewing medical records and histological slides from 2014-2024.
  • - The patients, primarily female with an average age of 61.2 years, presented mostly with solitary, asymptomatic nodules on the upper lip, and some experienced slight pain.
  • - The study emphasized distinct microscopic features of CAD and the utility of specific immunohistochemical markers in distinguishing CAD from other types of salivary gland tumors.
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Article Synopsis
  • A systematic review and meta-analysis evaluated the recurrence and progression risk of oral potentially malignant disorders (OPMD) and precancerous lesions after surgical treatments across various body sites.
  • Twelve studies were included, revealing that the variation in surgical protocols and unclear margin descriptions affected clinical outcomes, particularly for oral leukoplakia and anal intraepithelial neoplasia.
  • The analysis found no significant difference in recurrence risk between cold-knife and ablative treatments for oral leukoplakia and cervical intraepithelial neoplasia, highlighting the need for standardized surgical approaches.
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Objective: To assess the clinical scenarios in which nerve blocks are employed in the context of burning mouth syndrome (BMS).

Study Design: This scoping review followed the PRISMA-ScR. A protocol was generated on Open Science Framework.

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Article Synopsis
  • Oral focal mucinosis (OFM) is a rare, asymptomatic nodular lesion first identified in 1974, with an unclear cause, making diagnosis challenging due to its similarity to other conditions.
  • A systematic review of 42 studies revealed 113 cases, predominantly affecting women in their 40s, with the gingiva being the most common site.
  • Surgical removal is the preferred treatment, and accurate diagnosis relies on histopathological examination, positioning OFM as a potential differential diagnosis for benign soft tissue lesions in the oral cavity.
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Cancer disclosure represents a complex healthcare dynamic. Physicians or caregivers may be prompted to withhold diagnosis information from patients. This study aims to comprehensively map and synthesize available evidence about diagnosis nondisclosure regarding head and neck cancer (HNC) patients.

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