Blind multicenter study of the efficacy and safety of injections of a commercial preparation of botulinum toxin type A reconstituted up to 15 days before injection.

Background: It is recommended that attention be given to the shelf life of botulinum toxin type A (BT-A) after its reconstitution.

Objective: To assess the efficacy and safety of 500 U of BT-A after reconstitution up to 15 days after injection.

Material And Methods: BT-A vials were diluted 15 days, 8 days, and 8 hours before injection.

Clinical features of cutaneous and disseminated cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Paraty, Rio de Janeiro.

Background: American tegumentary leishmaniasis (ATL) caused by Leishmania (Viannia) braziliensis is endemic in Rio de Janeiro State (RJ), where the disease shows epidemiologic and clinical characteristics distinct from those of ATL in other Brazilian regions. Paraty is the second most important endemic area in RJ; however, reports on leishmaniasis in this region refer to the occurrence of the disease without describing its characteristics.

Methods: The clinical features of 71 cases of ATL reported between 1991 and 1997 in Paraty are presented.