Publications by authors named "Marcio Henrique de Oliveira Garcia"

In the municipality of Rio de Janeiro, Brazil, the incorporation of the concept of epidemic intelligence and technological resources has supported new perspectives for the use of data by health surveillance, since the COVID-19 pandemic. This article presents the Epidemiological Intelligence Center (CIE) and the tools and products developed in its coordination. The CIE was inaugurated in March 2022, with a multiprofessional team, supported by the premises of transparency and integration of various data sources for early detection of changes in the trends of events of importance in Public Health.

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Objective: To describe the profile of cases of mpox in the city of Rio de Janeiro between June and November 2022.

Methods: This was a descriptive study of secondary data obtained from mpox notification forms. Socioeconomic, clinical and spatial data were analyzed.

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COVID-19 vaccination during pregnancy is safe and effective in reducing the risk of complications. However, the uptake is still below targets worldwide. This study aimed to explore the factors associated with COVID-19 vaccination uptake among pregnant women since data on this topic is scarce in low-to-middle-income countries.

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Article Synopsis
  • An outbreak of scurvy-like illness occurred among male inmates in a Ceará prison, primarily affecting those over 40 years old, with symptoms including lower limb edema, pain, and difficulty walking.
  • The study highlights the importance of understanding scurvy outbreaks in similar contexts, contributing to better health service practices through epidemiological research.
  • Preventative strategies and policies targeting hypovitaminosis in incarcerated populations are necessary, alongside improvements in health services' ability to identify and manage such cases effectively.
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Background: COVID-19 vaccines have been shown to protect pregnant individuals against mild and severe COVID-19 outcomes. However, limited safety data are available for inactivated (CoronaVac) and mRNA (BNT162b2) vaccines during pregnancy regarding their effect on birth outcomes and neonatal mortality, especially in low- and middle-income countries.

Methods: We conducted a retrospective population-based cohort study in Rio de Janeiro, Brazil, with 17 513 singleton live births conceived between 15 May 2021 and 23 October 2021.

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Objective: To evaluate excess mortality in the city of Rio de Janeiro, Brazil, due to the COVID-19 pandemic (March 2020 to January 2022).

Methods: Ecological study using secondary data from the Brazilian Mortality Information System, having the city of Rio de Janeiro as the unit of analysis. Excess mortality was estimated by the difference between the mean number of all expected deaths and the mean number of observed deaths, considering the 2015-2019 period.

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Background: A vaccination campaign targeted adults in response to the pandemic in the City of Rio de Janeiro.

Objective: We aimed to evaluate the seroprevalence of SARS-CoV-2 antibodies and identify factors associated with seropositivity on vaccinated and unvaccinated residents.

Methods: We performed a seroepidemiologic survey in all residents of Paquetá Island, a neighborhood of Rio de Janeiro city, during the COVID-19 vaccine roll-out.

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Article Synopsis
  • During the first semester of 2021, Brazil faced a severe COVID-19 wave linked to the Gamma variant, with Delta variant cases emerging in July in Rio de Janeiro.
  • Researchers analyzed over 1,600 genomic sequences of the Delta variant to understand its spread, noting its initial concentration in Rio de Janeiro city before reaching other areas.
  • The Delta variant likely replaced Gamma due to a higher viral load, leading to increased case numbers but lower mortality rates, potentially aided by high vaccination rates in the region.
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Article Synopsis
  • This study presents the first documented case of intra-host recombination of SARS-CoV-2, involving two variants of concern: AY.33 (Delta) and P.1 (Gamma).
  • Using next-generation sequencing, the researchers identified six recombinant regions across the SARS-CoV-2 genome, particularly in the spike and nucleocapsid genes, showcasing a mix of mutations from both variants.
  • The findings highlight a potential public health risk, as the emergence of new recombinant viruses could complicate COVID-19 management and response efforts.
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The present report describes the implementation of an emergency operations center to coordinate the response to the COVID-19 pandemic in the municipality of Rio de Janeiro, Brazil. Following the public health emergency management framework proposed by the World Health Organization (WHO), this temporary center (COE COVID-19 RIO) started operating in January 2021. The report is organized along five themes: legal framework; structure, planning, and procedures; institutional articulation; health information for decision-making; and risk communication.

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In the present study, we provide a retrospective genomic epidemiology analysis of the SARS-CoV-2 pandemic in the state of Rio de Janeiro, Brazil. We gathered publicly available data from GISAID and sequenced 1927 new genomes sampled periodically from March 2021 to June 2021 from 91 out of the 92 cities of the state. Our results showed that the pandemic was characterized by three different phases driven by a successive replacement of lineages.

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Objective: to describe the results of Rapid Monitoring Vaccination monitoring conducted with the aim of interrupting the measles outbreak in the State of Ceará, Brazil, in 2015.

Methods: this was a descriptive study using data taken from 52,216 vaccination cards of children aged from 6 months to less than 5 years and data on vaccination coverage, homogeneity, and reasons for non-vaccination extracted from the National Immunization Program Information System (SI-PNI).

Results: vaccination coverage against measles reached 96.

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Objective: to describe the temporal and spatial distribution of reported and confirmed cases of congenital Zika virus syndrome (CZS) in live births in Brazil during 2015-2016.

Methods: we conducted a descriptive study with data from the Public Health Events Registry, including cases born in 2015 or 2016, and registered between epidemiological week 45/2015 and 2/2017.

Results: we analyzed 9.

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This study describes the experience and results of the vaccination strategies developed for tackling the measles outbreak in Ceará State, Brazil, from December 2013 to September 2015. Strategies of routine vaccination, community immunity, and vaccination campaigns were conducted, along with searching of unvaccinated people, through rapid monitoring of immunization coverage and scanning. To describe the results, primary data collected in field activities and secondary data on vaccination in a population aged from six months to 49 years, available at the Information System of the National Immunization Program (IS-NIP), were used.

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The measles virus circulation was halted in Brazil in 2001 and the country has a routine vaccination coverage against measles, mumps and rubella higher than 95%. In Ceará, the last confirmed case was in 1999. This article describes the strategies adopted and the effectiveness of surveillance and control measures implemented during a measles epidemic in the post-elimination period.

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Objective: to describe the real-time active surveillance strategy and the profile of health care provided during the 20th FIFA World Cup Brazil 2014 (FWCB), in the host city of Fortaleza, Ceará, Brazil.

Methods: this was a descriptive study with data collected from medical records during the FWCB, between June 8 and July 13, 2014, in pre-selected health care units.

Results: there were 2,570 medical assistances related to the FWCB; 56% of the patients were male, 35% were between 20 and 29 years old; 68% were clinical care, and 64% of the individuals were fans/spectators; 94% of the patients were discharged, 3% were referred, 3% were hospitalized and 0.

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An epidemic of infections after video-assisted surgery (1,051 possible cases) caused by rapidly growing mycobacteria (RGM) and involving 63 hospitals in the state of Rio de Janeiro, Brazil, occurred between August 2006 and July 2007. One hundred ninety-seven cases were confirmed by positive acid-fast staining and/or culture techniques. Thirty-eight hospitals had cases confirmed by mycobacterial culture, with a total of 148 available isolates recovered from 146 patients.

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