Publications by authors named "Marcio Alexandre Pena-Pereira"
Article Synopsis
- Restless legs syndrome (RLS) is a common issue in Parkinson's disease, leading to poor quality of life and excessive daytime sleepiness.
- A study with 88 Parkinson's patients found that 25 individuals had RLS, highlighting connections to loss of smell, sleep quality, and overall life quality.
- Women with RLS also showed higher rates of insomnia, constipation, and anosmia compared to those without RLS, indicating specific risk factors within this group.
Introduction: A diagnosis of rapid eye movement sleep behavior disorder (RBD) currently requires confirmation with polysomnography (PSG). However, PSG may not be sufficiently available. In these situations, a clinical diagnostic measure might be useful.
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- Obstructive sleep apnea (OSA) affects up to 66% of Parkinson's disease (PD) patients, a rate significantly higher than in the general population, but the exact relationship between the two is still debated.
- A study involving 88 PD patients found that those with OSA were typically older and experienced less insomnia, but exhibited worse sleep quality as indicated by polysomnography results, specifically showing lower N3 sleep percentage and higher oxygen desaturation.
- The study concluded that while OSA is prevalent in PD patients, sleeping in a supine position seems to have a significant role in its occurrence, and certain typical risk factors for OSA in the general population may not apply as strongly to PD patients.
Article Synopsis
- - Insomnia affects up to 55% of Parkinson disease (PD) patients, influenced by the disease's progression, aging-related issues, and medication effects.
- - A study with 63 PD patients evaluated insomnia factors through clinical interviews and standardized assessments, including sleep quality scales and video-polysomnography.
- - Key findings highlighted that chronic insomnia in PD is linked to poor sleep habits, long REM sleep latency, better sleep quality, and a lack of obstructive sleep apnea.
Background: Idiopathic focal dystonia is a motor syndrome associated with dysfunction of basal ganglia circuits. Observations have suggested that many other non-motor symptoms may also be part of the clinical picture. The aim was to assess the prevalence and correlation of non-motor symptoms in patients with common idiopathic focal or segmental dystonia.
View Article and Find Full Text PDFEpidemiological and clinical aspects of a sample of Brazilian patients with primary dystonia and the impact of the new classification on their clinical evaluation.
Arq Neuropsiquiatr
December 2018
Dystonia is a relatively common movement disorder but some of its epidemiological and clinical aspects have not been well characterized in Brazilian patients. Also, a new clinical classification for the disorder has been proposed and its impact on clinical practice is unclear. We aimed to describe the clinical and demographic characteristics of a Brazilian series of patients with primary dystonia, to estimate its local prevalence, and to explore the impact of using a new classification for dystonia.
View Article and Find Full Text PDFIntroduction: Excessive sleepiness (ES) can affect up to 60% of Parkinson's disease (PD) patients, and it has a multifactorial etiology. It is related to the neurodegenerative processes affecting brain regions responsible for the sleep-wake cycle, the effects of drugs acting on the central nervous system, and the excessive sleep fragmentation of this population.
Objectives: To identify the factors associated with the presence of ES in patients with PD.
Article Synopsis
- A study was conducted on 88 Parkinson's disease patients to evaluate the occurrence of major sleep disorders using various assessment tools and techniques.
- The findings revealed that 96.5% of participants experienced sleep disorders, including REM-sleep behavior disorder (62.5%), obstructive sleep apnea (62.5%), and insomnia (55.7%).
- There is a significant correlation between sleep quality and the overall quality of life, indicating that poor sleep and daytime sleepiness negatively impact these patients' daily experiences.
Objective And Background: Excessive fragmentary myoclonus (EFM) is characterized by subtle arrhythmic and excessive jerks that are usually asymmetric and asynchronous. EFM occurs in different areas of the body, mainly the face and distal parts of the arms and legs, and is detected by surface electromyography during sleep. The present study aimed to determine the prevalence of EFM in Parkinson's disease (PD) patients at a tertiary level outpatient clinic as well as to describe the clinical and polysomnographic profiles of these patients.
View Article and Find Full Text PDFIntroduction: Parkinson's disease (PD) has a progressive course and is characterized by the degeneration of dopaminergic neurons. Although no neuroprotective treatments for PD have been found to date, the endocannabinoid system has emerged as a promising target.
Methods: From a sample of 119 patients consecutively evaluated in a specialized movement disorders outpatient clinic, we selected 21 PD patients without dementia or comorbid psychiatric conditions.