Solubilizing and lithogenolitic properties of water solutions of non-ionic surfactants of cholesterol oxyethylenation products.

Research was conducted into the properties and identity of the products oxyethylenation of cholesterol, which were obtained with the use of a selective catalyst (K-4) and standard alkaline catalyst (Na/NaOH). The 1HNMR method was employed to assess the content of oxyethylated segments and the analytic level of hydrophilic--lipophilic balance (HLB). Basic viscosity and hydrodynamic values were determined for the solubilizers and their micellar adduct with ibuprofen, ketoprofen, naproxen and cholesterol.

Solubilizing properties of new surface-active agents, products of selective oxyethylation of cholic acid. Part I.

Research was conducted into the properties and identity of the products of oxyethylation of cholic acid, which were obtained with the use of a selective catalyst (K4). The 1HNMR method was employed to assess the content of oxyethylated segments and the analytic level of hydrophilic-lipophilic balance (HLB). Surface activity of the products of oxyethylation in water and 0.

Polyoxyethylenated methyl esters of rape oil fatty acids as non-ionic surfactants in a model drug form with albendazole.

Systematic research has been conducted on the applying of Rofams (oxyethylathed rape oil methyl esters) as solubilizing agents of albendazole. Homologous series of Rofams containing average amount of oxyethylene units (nTE) ranging between 20 to 60 was used for investigation. An attempt has been made to apply investigated surface active agents as an auxiliary in production of model tablets with albendazole.

Equilibrium solubilization of diclofenac by aqueous solutions of the products of lanolin oxyethylenation.

Systematic research has been conducted on the products of catalytic oxyethylenation of lanolin. The level of hydrophilic-lipophilic balance HLB and the amount of oxyethylene segments nTE in homologous series of products were determined by means of the 1HNMR method. Viscosity and spectrophotometry measurements were used to determine solubilization indices n/s/, the micellar partition coefficient K(m)w, and the solubility quotient i25(r) of diclofenac in aqueous solutions of surfactants.