Publications by authors named "Marcin Filip Osuchowski"
Background: Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals. This study used a clinically relevant sepsis mouse model of peritoneal contamination and infection (PCI) to investigate the antinociceptive and anti-inflammatory properties of two non-opioid analgesics.
View Article and Find Full Text PDFThis manuscript emerged from a larger third-party funded project investigating a new poly-trauma model and its influence upon secondary sepsis. The present sub-study compared selected leukocyte subpopulations in the circulation and bone marrow after polytrauma in BALB/c versus CD-1 mice. Animals underwent unilateral femur fracture, splenectomy and hemorrhagic shock.
View Article and Find Full Text PDFArticle Synopsis
- PAI-1 is crucial in understanding coagulopathy arising from trauma and sepsis, and this study focuses on how trauma-hemorrhage affects PAI-1 levels in septic situations.
- The research involved experiments on mice, comparing PAI-1 levels in plasma and tissues before and after a cecal ligation and puncture (CLP) procedure to assess outcomes for survivors and non-survivors.
- Findings showed that trauma-induced changes in PAI-1 are compartment-specific and that elevated levels of circulating PAI-1 post-CLP could predict septic deaths, highlighting the significance of monitoring PAI-1 in trauma and sepsis management.
Age/gender may likely influence the course of septic complications after trauma. We aimed to characterize the influence of age/gender on the response of circulating cytokines, cells and organ function in post-traumatic sepsis. We additionally tested whether post-traumatic responses alone can accurately predict outcomes in subsequent post-traumatic sepsis.
View Article and Find Full Text PDFIntroduction: Plasminogen activator inhibitor type 1 (PAI-1) co-induces septic coagulopathy. We aimed to characterize spatiotemporal PAI-1 gene/protein changes occurring in acute sepsis and tested whether PAI-1 fluctuations correlate with sepsis severity and early outcome.
Materials And Methods: Female mice underwent cecal ligation and puncture (CLP) in three experiments.