Impact of missing data imputation methods on gene expression clustering and classification.

Background: Several missing value imputation methods for gene expression data have been proposed in the literature. In the past few years, researchers have been putting a great deal of effort into presenting systematic evaluations of the different imputation algorithms. Initially, most algorithms were assessed with an emphasis on the accuracy of the imputation, using metrics such as the root mean squared error.

Clustering cancer gene expression data: a comparative study.

Background: The use of clustering methods for the discovery of cancer subtypes has drawn a great deal of attention in the scientific community. While bioinformaticians have proposed new clustering methods that take advantage of characteristics of the gene expression data, the medical community has a preference for using "classic" clustering methods. There have been no studies thus far performing a large-scale evaluation of different clustering methods in this context.

Equivalence between RAM-based neural networks and probabilistic automata.

In this letter, the computational power of a class of random access memory (RAM)-based neural networks, called general single-layer sequential weightless neural networks (GSSWNNs), is analyzed. The theoretical results presented, besides helping the understanding of the temporal behavior of these networks, could also provide useful insights for the developing of new learning algorithms.