Publications by authors named "Marcilei Eliza Cavichiolli Buim"
Article Synopsis
- This study investigates the expression of the VEGFA gene and protein in oral squamous cell carcinoma (OSCC) and its tumor margins, given the importance of new blood vessel formation for tumor growth.* -
- Researchers analyzed gene expression in cryopreserved samples from OSCC, tumor margins, and normal mucosa, finding that VEGFA levels were significantly higher in OSCC and tumor margins compared to healthy tissue.* -
- The findings suggest that high VEGFA expression correlates with more aggressive forms of OSCC and implies that tumor margins contribute to angiogenesis, highlighting VEGFA as a potential prognostic indicator for this cancer.*
Background: Sonic hedgehog (SHH) pathway activation has been identified as a key factor in the development of many types of tumors, including odontogenic tumors. Our study examined the expression of genes in the SHH pathway to characterize their roles in the pathogenesis of keratocystic odontogenic tumors (KOT) and ameloblastomas (AB).
Methods: We quantified the expression of SHH, SMO, PTCH1, SUFU, GLI1, CCND1, and BCL2 genes by qPCR in a total of 23 KOT, 11 AB, and three non-neoplastic oral mucosa (NNM).