Publications by authors named "Marcie Jimenez"
Ultrastructural features of striatal white matter and cells in an in vivo model of glutaric acidemia type I created by intracerebral injection of glutaric acid (GA) were analyzed by transmission electron microscopy and immunohistochemistry. To test if the white matter damage observed in this model could be prevented, we administered the synthetic chemopreventive molecule CH38 ((E)-3-(4-methylthiophenyl)-1-phenyl-2-propen-1-one) to newborn rats, previous to an intracerebroventricular injection of GA. The study was done when striatal myelination was incipient and when it was already established (at 12 and 45 days post-injection [DPI], respectively).
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- Glutaric acid (GA) is a harmful substance that builds up in the brains of people with a disease called glutaric acidemia-I, which happens when a certain important enzyme doesn't work properly.
- In experiments with baby rats, when GA was put in their brains, it caused serious problems with myelination (the process that helps nerves work well) in a part of the brain called the striatum, while not affecting another area called the corpus callosum.
- This study shows that GA doesn't kill off a type of brain cell directly but seems to hurt them indirectly, leading to long-term issues with brain function.
Article Synopsis
- Scientists are studying how a substance called glutaric acid (GA) can harm brain cells called astrocytes during early life and possibly lead to problems with brain development later on.
- They tested this by giving GA to baby rats, which led to lots of changes in the astrocytes and some brain damage over time, even though there weren't immediate effects.
- The research suggests that GA can harm the brain by changing how astrocytes work, and using certain antioxidants might help protect against this damage.