Publications by authors named "Marcia de Berredo Pinho Moreira"
Article Synopsis
- Patients with leprosy can experience acute inflammatory episodes called erythema nodosum leprosum (ENL), which involve painful skin nodules and systemic symptoms; neutrophils are believed to contribute to these episodes.
- A study compared transcriptomic data from the blood of patients with non-reactional lepromatous leprosy and those experiencing ENL, revealing that ENL patients exhibited a heightened expression of neutrophil activation and pro-inflammatory genes.
- Validation of the findings showed that the level of the neutrophil activation marker CD177 could differentiate between ENL and non-reactional cases, and higher CD177 levels were associated with more severe ENL episodes, suggesting its potential as a marker for EN
Leprosy is a much-feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide. During host-pathogen interaction, M leprae subverts the immune response, leading to development of disease. Throughout the last few decades, the impact of energy metabolism on the control of intracellular pathogens and leukocytic differentiation has become more evident.
View Article and Find Full Text PDFExploring the "Latin American Mediterranean" family and the RD lineage in Mycobacterium tuberculosis isolates from Paraguay, Argentina and Venezuela.
BMC Microbiol
June 2019
Background: The Latin American & Mediterranean (LAM) spoligotype family is one of the most successful genotype of Mycobacterium tuberculosis worldwide and particularly prevalent in South-America. Within this family, a sublineage named Region of Difference Rio (RD) was reported initially in Brazil and is characterized by a genomic deletion of about 26.3 kb.
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