Late chimerical status after bone marrow transplantation in severe aplastic anemia according to two different preparatory regimens.

Background: This study investigated the influence of two conditioning regimens on the chimerical status of 104 patients with acquired severe aplastic anemia.

Methods: Patients were monitored for at least 18 months after related bone marrow transplantation and reaching partial or complete hematologic recovery. Group I patients ( = 55) received 200 mg/kg cyclophosphamide alone and Group II ( = 49) received 120 mg/kg cyclophosphamide associated with 12 mg/kg busulfan.