A simple and efficient synthesis of -[3-chloro-4-(4-chlorophenoxy)-phenyl]-2-hydroxy-3,5-diiodobenzamide, rafoxanide.

Unlabelled: A method for the synthesis of rafoxanide , a halogenated salicylanilide used as an efficient anthelmintic in sheep and cattle, is presented. Rafoxanide was synthesized in only three steps from readily available 4-chlorophenol with 74% overall yield. The synthesis has two key stages: the first was salicylic acid iodination, adding iodine in the presence of hydrogen peroxide, which allowed obtaining a 95% yield.

Ligand influence in electrocatalytic properties of Cu(II) triazole complexes for hydrogen peroxide detection in aqueous media.

In this work, electrocatalytic changes of Cu(II) triazole complexes (Cu(L)) resulting from inductive effects were evaluated to fabricate a sensor for hydrogen peroxide (HO) determination. Three copper(II) complexes with electronically differentiated ligands were synthesized by slow diffusion method and characterized by X-ray crystallography, Fourier transformed infrared (FTIR), UV-Vis, scanning electron microscopy (SEM) and voltammetry cyclic (CV). Cu(LOMe)2/GC, Cu(LBr)2/GC and Cu(LNO2)2/GC sensors were then prepared.

Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3)-quinazolinones 3-substituted.

A novel series of 6-iodo-2-methylquinazolin-4-(3)-one derivatives, 3a-n, were synthesized and evaluated for their cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed remarkable cytotoxic activity on specific human cancer cell lines when compared to the anti-cancer drug, paclitaxel. Compound 3a was found to be particularly effective on promyelocytic leukaemia HL60 and non-Hodgkin lymphoma U937, with IC values of 21 and 30 μM, respectively.

2-(4-Bromo-phen-yl)-N-[3-(1H-imidazol-1-yl)prop-yl]quinazolin-4-amine.

In the title compound, C(20)H(18)BrN(5), the bromo-phenyl-substituted quinazoline unit is essentially planar [maximum deviation = 0.098 (3) Å] and makes a dihedral angle of 56.04 (14)° with the imidazole ring.

2-Amino-N'-phenyl-benzohydrazide.

In the title compound, C(13)H(13)N(3)O, the NNCO unit forms dihedral angles of 35.8 (1) and 84.0 (1)° with the benzene and phenyl rings, respectively.

1-(2,4-Difluoro-phen-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol.

In the title compound, C(10)H(9)F(2)N(3)O, the dihedral angle between the mean planes of the triazole and benzene rings is 20.6 (2)°. In the crystal, mol-ecules are linked by strong O-H⋯ N hydrogen bonds into chains with graph-set notation C(9) along [100].