Carnoy solution versus GEWF solution for lymph node revealing in colorectal cancer: a randomized controlled trial.

Purpose: This study aimed to compare the performance of two lymph node revealing solutions.

Methods: This randomized clinical trial (NTC02704988) investigated patients with colon or rectal cancer who underwent surgical resection with D2 lymphadenectomy. Specimens submitted for conventional pathological examination were randomly assigned for additional fixation with Carnoy or GEWF solution, and dissection was performed to examine the missed lymph nodes.

H4K12 and H3K18 Acetylation Associates With Poor Prognosis in Pancreatic Cancer.

Background/objectives: Epigenetic deregulation may be involved in tumor cell biology, including differentiation, tumor progression, and cell death, and histone acetylation is a major regulatory mechanism of gene transcription. Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients, but few studies have been conducted on pancreatic ductal adenocarcinomas (PDACs). This study was designed to investigate the predictive value of histone acetylation modifications on PDAC.