A high-fat meal impairs muscle vasodilatation response to mental stress in humans with Glu27 beta2-adrenoceptor polymorphism.

Background: Forearm blood flow responses during mental stress are greater in individuals homozygous for the Glu27 allele. A high-fat meal is associated with impaired endothelium-dependent dilatation. We investigated the impact of high-fat ingestion on the muscle vasodilatory responses during mental stress in individuals with the Glu27 allele and those with the Gln27 allele of the beta2-adrenoceptor gene.

Abnormal neurovascular control during sympathoexcitation in obesity.

Objective: We tested the hypothesis that muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) would be augmented during mental stress or cold pressor test in healthy obese individuals compared with healthy lean individuals.

Research Methods And Procedures: Twenty-nine healthy obese women and 12 age-matched healthy lean women were involved in the study. MSNA was directly measured from the peroneal nerve using microneurography.

Weight loss improves neurovascular and muscle metaboreflex control in obesity.

We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 +/- 1.4 yr, body mass index: 34.