Publications by authors named "Marcia L G Perfeito"
Antimicrobial activity of nanoparticles based on carboxymethylated cashew gum and epiisopiloturine: In vitro and in silico studies.
Int J Biol Macromol
August 2024
Epiisopiloturine (EPI) is a compound found in jaborandi leaves with antiparasitic activity, which can be enhanced when incorporated into nanoparticles (NP). Cashew Gum (CG), modified by carboxymethylation, is used to produce polymeric nanomaterials with biological activity. In this study, we investigated the antimicrobial potential of carboxymethylated CG (CCG) NP containing EPI (NPCCGE) and without the alkaloid (NPCCG) against bacteria and parasites of the genus Leishmania.
View Article and Find Full Text PDFEthnopharmacological Relevance: There are ethnopharmacological reports supporting the use of neem (Azadirachta indica A. Juss) leaf against bacterial and worm infections. However there is a lack of studies about its effect on bacterial biofilm formation and Schistosoma mansoni worms.
View Article and Find Full Text PDFArticle Synopsis
- * The peptides varied in structure, with some being amidated and others having free carboxylates, showing similarities to other peptides from the same frog genus.
- * Antimicrobial tests revealed that all peptides, except one, were effective against at least one strain of Gram-negative bacteria, with the most potent peptide, ocellatin-PT8, inhibiting multiple harmful bacteria without affecting human cells at tested concentrations.
Background: The methicillin resistance of bacteria from the genus Staphylococcus and its ability to form biofilms are important factors in pathogenesis of these microorganisms. Thus, the search for new antimicrobials agents, especially from plants, has been intensified. In this context, Terminalia species have been the subject of research for many pharmacological activities.
View Article and Find Full Text PDF