Publications by authors named "Marcia Helena Oyafuso"
Article Synopsis
- Dexamethasone acetate (DEX) is an effective anti-inflammatory drug used for treating various inflammatory and autoimmune conditions, and it has been integrated into CETETH 20-based liquid crystalline systems to improve its delivery.
- A High-Performance Liquid Chromatography (HPLC) method was developed and validated to measure the amount of DEX in these systems, utilizing specific conditions for accurate detection.
- The HPLC method showed high accuracy (99.92%) and excellent precision, allowing for the effective evaluation of DEX incorporation in the new formulation, making it suitable for use in pharmaceutical labs globally.
Nanotechnology offers advantages for new drug delivery design by providing drug targeting while minimizing the side effects. Polyoxyethylene 20 cetyl alcohol (CETETH-20) is a surfactant that may form nanostructured systems, such as liquid crystals, when in contact with water/oil, which are structurally similar to biological membranes and may improve skin interaction. The aim of this study was to develop and characterize CETETH 20-based nanostructured systems by combining CETETH-20 with water and different oily phases, including PEG-12-dimethicone for topical drug administration.
View Article and Find Full Text PDFMelanoma (MEL) is a less common type of skin cancer, but it is more aggressive with a high mortality rate. The World Cancer Research Fund International (GLOBOCAN 2012) estimates that there were 230,000 new cases of MEL in the world in 2012. Conventional MEL treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties.
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