Publications by authors named "Marcia Garcez"
Lung branching morphogenesis relies on intricate epithelial-mesenchymal interactions and signaling networks. Still, the interplay between signaling and energy metabolism in shaping embryonic lung development remains unexplored. Retinoic acid (RA) signaling influences lung proximal-distal patterning and branching morphogenesis, but its role as a metabolic modulator is unknown.
View Article and Find Full Text PDFThe fate and proliferative capacity of stem cells have been shown to strongly depend on their metabolic state. Mitochondria are the powerhouses of the cell being responsible for energy production oxidative phosphorylation (OxPhos) as well as for several other metabolic pathways. Mitochondrial activity strongly depends on their structural organization, with their size and shape being regulated by mitochondrial fusion and fission, a process known as mitochondrial dynamics.
View Article and Find Full Text PDFWhether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied how body organs communicate to regulate growth during development by looking into the Drosophila Lgr3 gene, which is similar to an orphan relaxin receptor.
- They discovered that mutations in Lgr3 led to body asymmetries akin to those seen in insulin-like peptide 8 (dilp8) mutants, indicating a failure to coordinate growth with developmental timing.
- By identifying specific neurons that respond to growth signals, this study uncovers a new neuroendocrine circuit that could be important for understanding growth regulation in organisms.
Objective: To analyze oxidative stress markers and seminal standard parameters after using resveratrol (0.1, 1.0, and 10.
View Article and Find Full Text PDFCryopreservation of human semen can cause DNA damages, which compromise the fertilization and normal embryo development. The present study showed that the antioxidant resveratrol prevents these damages both in fertile and infertile men. The addition of ascorbic acid before cryopreservation can reduce DNA damages only in infertile men.
View Article and Find Full Text PDFObjective: To evaluate the levels of thiobarbituric acid reactive substances (TBARS), uric acid, and seric superoxide dismutase and catalase activities, as well as total serum iron, total iron-binding capacity (TIBC), erythrocyte osmotic fragility, and hemograms in people with Down syndrome.
Participants And Methods: The study sampled (July to December 2003) 50 people with Down syndrome and 50 individuals without Down syndrome (control group) matched by age and sex. The levels of TBARS were measured by the TBARS method.