Mono-Locus and Pyramided Resistant Grapevine Cultivars Reveal Early Putative Biomarkers Upon Artificial Inoculation With .

One of the most economically important grapevine diseases is Downy mildew (DM) caused by the oomycete . A strategy to reduce the use of fungicides to compensate for the high susceptibility of is the selection of grapevine varieties showing pathogen-specific resistance. We applied a metabolomics approach to evaluate the metabolic modulation in mono-locus resistant genotypes carrying one locus associated with resistance () (BC4- , Bianca- , F12P160- , Solaris- ), as well as in pyramided resistant genotypes carrying more than one (F12P60- and F12P127- ) taking as a reference the susceptible genotype Pinot Noir.