A systematic study on the activation of simple polyethers by MoCl5 and WCl6.

MoCl(5), 1a, and WCl(6), 1b, activate 1,3-dioxolane at room temperature in chlorinated solvents: the compound [MoOCl(3){O=C(H)OCH(2)CH(2)Cl}](2), 2, has been isolated from MoCl(5)/dioxolane. The mixed oxo-chloro species WOCl(4), 1c, reacts with 1,3-dioxolane, selectively giving the coordination adduct WOCl(4)(kappa(1)-C(3)H(6)O(2)), 3. Dimethoxymethane, CH(2)(OMe)(2), undergoes activation including C-H bond cleavage when reacted with 1a to give the molybdenum complexes [MoOCl(3){O=C(H)OMe}](2), 4, and Mo(2)Cl(5)(OMe)(5), 5.

Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities.

A series of Cu(II), Zn(II) and Mn(II) coordination compounds has been synthesized by reaction of the corresponding metal salts and pyrazolyl-based ligands, i.e. the neutral 1-(2-(4-((2,2,2-tri(1H-pyrazol-1-yl)ethoxy)methyl)benzyloxy)-1,1-di(1H-pyrazol-1-yl)ethyl)-1H-pyrazole {p-C(6)H(4)[CH(2)OCH(2)C(pz)(3)](2), (L(1)), and the anionic hydridotris(3-phenyl-5-methylpyrazolyl)borate (L(2))(-), bis(pyrazolyl)acetate (L(3)) and bis(3,5-dimethylpyrazolyl)acetate (L(4))(-): the species [L(1)(CuCl(2))(2)] (1), [L(1)(Cu(OAc)(2))(2)] (2), [L(1)(Zn(OAc)(2))(2)] (3), [(CuCl(L(2))(Hpz(Ph,Me))] (4), [Mn(L(3))(2)].

Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.

CDK2 inhibitory structure-activity relationships have been explored for a range of 5-substituted O(4)-alkylpyrimidines. Variation of the 5-substituent in the 2,6-diaminopyrimidine series confirmed the 5-nitroso substituent as optimal, and showed that 5-formyl and 5-acetyl substituents were also tolerated at this position. A series of O(4)-alkyl-N(2)-aryl-5-substituted-6-aminopyrimidines revealed interesting structure-activity relationships.

Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy.

Background: Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S.

[3+2+1] cycloaddition involving alkynes, CO and bridging vinyliminium ligands in diiron complexes: a dinuclear version of the Dötz reaction?

The vinyliminium complex [Fe2{mu-eta(1):eta(3)-C(SiMe3)=CHC=N(Me)2}(mu-CO)(CO)(Cp)2][SO3CF3] reacts with HC[triple bond]CR (R = CPh2OH), affording a mixture of the 2,4,6-trisubstituted oxo-eta(5)-cyclohexadienyl complex [Fe{eta(5)-C6H2O(NMe2)(SiMe3)(R)}(Cp)], the 2,6-disubstituted phenol C6H3R(NMe2)OH (R = CHPh2) and 1,2,4-trisubstituted ferrocene [1-NMe2-2-R-4-SiMe3-Fc]. The corresponding reaction with HC[triple bond]CR (R = CMe2OH) yields analogous products: [Fe{eta(5)-C6H2O(NMe2)(SiMe3)(R')}(Cp)] (R' = CMe=CH2), the phenol C6H3R'(NMe2)OH together with [1-NMe2-2-R-4-SiMe3-Fc].

Non-classical anticancer agents: synthesis and biological evaluation of zinc(II) heteroleptic complexes.

New heteroleptic complexes (1-8) containing Zn(II) ion coordinated to an N,N-chelating ligand (the 4,4'-dinonyl-2,2'-bipyridine, bpy-9) and to diketonates L such as tropoloids (Tropolone and Hinokitiol) or 1-phenyl-3-methyl-4-R-5-pyrazolones have been synthesized by using different stoichiometric ratio with respect to the L ancillary ligand. The molecular structure of the bis-tropolonate derivative [(bpy-9)Zn(L)(2)] 5 has been determined by single-crystal X-ray diffraction. The antitumour activity of all Zn(II) complexes was tested in vitro against three different human prostate cancer cells: DU145, LNCaP and PC-3.

The use of the Veress needle to drain mammary periprosthetic fluid.

Background: The most common early complications associated with mammary implants are seroma and haematoma formation, and acute infection. The aspiration of fluid around the prosthesis can help to diagnose and correctly treat these complications. The use of a needle with a sharp tip can damage the implant.

[Breast cancer metastasis in distal phalanx of the big toe. Case report].

Breast cancer represents the most prevalent malignancies in women and bone is the first site of metastasis in 26-50% of cases. Usually metastasis involve limbs in 16%. We present a rare case of 47-year-old woman, who underwent to monolateral mastectomy for lobular cancer.

Syntheses, structures and spectroscopy of uni- and bi-dentate nitrogen base complexes of silver(I) trifluoromethanesulfonate.

In extension of recent synthetic and crystallographic studies of adducts of silver(I) oxyanion salts with uni- and bi-dentate nitrogen-donor ligands, AgX : L (1 : n), a parallel series of complexes formed with silver(I) trifluoromethanesulfonate ('tfs', 'triflate') has been similarly defined, showing rather more divergence from tendencies established with the previous ClO(4), NO(3), F(3)CCO(2) core arrays than might be expected from basicity arguments. Thus, while silver triflate crystallised from neat base forms 1 : 2 mononuclear adducts with 2,4,6-trimethylpyridine and quinoline which comprise essentially linear two-coordinate [LAgL](+) cations, perturbed by approaches of the anions, 1 : 2 adducts obtained similarly from pyridine and 2-methylpyridine are [L(2)Ag(mu-tfs)(2)AgL(2)] dimers, with central four- and eight-membered rings arising from mu-OSO(2)CF(3) and extended mu-(O,O'SOCF(3)) anion bridging modes, respectively. With piperidine, a single-stranded polymer reminiscent of the arrays [(pip)(2)AgX](infinity/infinity), X = Cl, NCS, is formed, the triflate bridging through two of its oxygen atoms, rather than via a single atom bridge.

The multiple roles of Bub1 in chromosome segregation during mitosis and meiosis.

Aneuploidy, any deviation from an exact multiple of the haploid number of chromosomes, is a common occurrence in cancer and represents the most frequent chromosomal disorder in newborns. Eukaryotes have evolved mechanisms to assure the fidelity of chromosome segregation during cell division that include a multiplicity of checks and controls. One of the main cell division control mechanisms is the spindle assembly checkpoint (SAC) that monitors the proper attachment of chromosomes to spindle fibers and prevents anaphase until all kinetochores are properly attached.

Structures and unusual rearrangements of coordination adducts of MX(5) (M = Nb, Ta; X = F, Cl) with simple diethers. A crystallographic, spectroscopic, and computational study.

High-yield reactions of the pentafluoride complexes MF(5) (M = Nb, Ta) with a variety of diethers, ROCH(2)CH(R')OR'', afford the ionic derivatives [MF(4){kappa(2)-ROCH(2)CH(R')OR''}(2)][MF(6)] (2a-2e) or [MF(4){ROCH(2)CH(R')OR''}(2)][M(2)F(11)] (3a-3f) according to the metal/diether ratio employed. The structures of [MF(4)(kappa(2)-dme)(2)][MF(6)] [M = Nb (2a), Ta (2b); dme = MeOCH(2)CH(2)OMe] have been determined by X-ray diffraction. Moreover, the structure of the cationic part of 2a in the gas phase has been optimized by density functional theory calculations (the B3LYP/LANL2DZ method).

Double adverse drug reaction: Recombinant human growth hormone and idiopathic intracranial hypertension - acetazolamide and metabolic acidosis: a case report.

A 9-year-old girl, treated for growth hormone deficiency, developed bitemporal progressive headache, diplopia, acute comitant esotropia and visual loss 3 months after starting recombinant growth hormone. An increased intracranial pressure was revealed by examination of ocular fundus and lumbar puncture, and the absence of other causes, ruled out through a brain scan, led to the diagnosis of idiopathic intracranial hypertension.Recombinant growth hormone was discontinued and acetazolamide started up to 30 mg/kg/die without any clinical improvement but developing metabolic acidosis.

Stability and pairing in quasi-one-dimensional Bose-Fermi mixtures.

We consider a mixture of single-component bosonic and fermionic atoms in an array of coupled one-dimensional "tubes." For an attractive Bose-Fermi interaction, we show that the system exhibits phase separation instead of the usual collapse. Moreover, above a critical intertube hopping, all first-order instabilities disappear in both attractive and repulsive mixtures.

The reactivity of 1,1-dialkoxyalkanes with niobium and tantalum pentahalides. Formation of coordination compounds, C-H and C-C bond activation and the X-ray structure of the stable carboxonium species [Me(2)C=CHC(=OMe)Me][NbCl(5)(OMe)].

The reactions of the pentahalides NbX5 (X = Cl, Br) with the 1,1-dialkoxyalkanes CHR'(OEt)2 or 1,3-dioxolane yield the coordination adducts NbX5[kappa1-(OEt)CHR'(OEt)] (X = Cl, R' = H, 2a; X = Br, R' = H, 2b; X = Cl, R' = Me, 2c; X = Br, R' = Me, 2d) or NbCl5(kappa1-right angle OCH2OCH2C right angle H2), 3, respectively. Compounds 2a-c and 3 are stable at room temperature, while 2d slowly converts into the alkoxide NbBr4[OCH(Me)OEt], 4. Room-temperature fragmentations are observed upon reacting CH2(OMe)2, CHMe(OMe)2 and CMe2(OMe)2 with MX5 (M = Nb, Ta; X = Cl, Br).

Fragmentation of oxygen-containing molecules via C-O bond cleavage promoted by coordination to niobium and tantalum pentahalides.

The novel mu-oxo complexes NbOX(3)[kappa(2)-O(Me)CH(2)CO(2)Me]NbX(5) (X = Cl, ; X = Br, ), NbOCl(3)[kappa(2)-(MeO(2)C)CH[double bond, length as m-dash]CH(CO(2)Me)]NbCl(5) () and NbOCl(3)[kappa(2)-CH(2)(CO(2)Me)(2)]NbCl(5) () have been prepared in good yields by 1 : 1 molar ratio reactions of the halides NbX(5) (X = Cl, Br) with methoxymethyl acetate [MeOCH(2)CO(2)Me], dimethyl maleate [(MeO(2)C)CH[double bond, length as m-dash]CH(CO(2)Me)] and dimethyl malonate [CH(2)(CO(2)Me)(2)] respectively, in different experimental conditions. NMR studies have indicated that the oxo unit of , and forms via selective fragmentation (C-O bonds cleavage) of half equivalent of the organic material. The ionic complexes [NbX(4){O-O}(2)][NbX(6)] [X = Cl, O-O = MeOCH(2)CO(2)Me, ; X = Cl, O-O = (MeO(2)C)CH[double bond, length as m-dash]CH(CO(2)Me), ; X = Cl, O-O = CH(2)(CO(2)Me)(2), ] have been identified as intermediates of the reactions affording , and .

Inhibitory effect of beta-diketones and their metal complexes on TNF-alpha induced expression of ICAM-1 on human endothelial cells.

Recent reports show that the natural beta-diketone curcumin displays important biological properties regarding the intercellular adhesion molecule-1 (ICAM-1), which plays a critical role in the immune responses and inflammation. In this study the ICAM-1 inhibitory activity of beta-diketone compounds, which are curcumin models lacking aromatic peripheral hydroxyl and methoxy groups, along with some metal derivatives is investigated. Beta-diketones are systematically more active than metal complexes and the best obtained inhibition is 75% for both groups.

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.

Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here, we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy in female germ cells of mice and that the effect increases with advancing maternal age. Analysis of Bub1 heterozygous oocytes showed that aneuploidy occurred primarily during the first meiotic division and involved premature sister chromatid separation.

Designing a serious game for young users: the case of happy farm.

The interactivity and attractiveness of video games are increasingly deployed for educational and training purposes in what are called "serious games." This paper describes Happy Farm, a serious game targeting young people and aimed at increasing their awareness of the risks connected to the consumption of psychoactive substances. The development of the game is driven by the premise that credibility and usability are pre-conditions for persuasion.

Measuring public health officers' opinions on new vaccination programs by means of the WHO Vaccine Introduction Guidelines.

A group of public health officers and gynecologists were requested to express their opinion on whether immunization for: HPV in girls older than 12 years, varicella with combined MMRV vaccine and rotavirus (RV) should be included in the National Immunization Plan in Italy. For each of the three immunization programs, a specific questions list was prepared following the eight steps of the WHO Vaccine Introduction Guidelines flowchart. For each immunization strategy, a logistic regression model was used to identify the set of topics which, jointly considered, showed the strongest influence on the final responder's statement.