Comparative Surfaceome Analysis of Clonal Strains with Different Pathogenicity Reveals Strain-Dependent Profiles.

a poultry-specific intestinal protozoan parasite, is histomonosis's etiological agent. Since treatment or prophylaxis options are no longer available in various countries, histomonosis can lead to significant production losses in chickens and mortality in turkeys. The surfaceome of microbial pathogens is a crucial component of host-pathogen interactions.

Complete genomes of the eukaryotic poultry parasite Histomonas meleagridis: linking sequence analysis with virulence / attenuation.

Background: Histomonas meleagridis is a protozoan parasite and the causative agent of histomonosis, an important poultry disease whose significance is underlined by the absence of any treatment and prophylaxis. The recent successful in vitro attenuation of the parasite urges questions about the underlying mechanisms.

Results: Whole genome sequence data from a virulent and an attenuated strain originating from the same parental lineage of H.