The electrocardiographic features of complete and partial left anterior and left posterior hemiblock.

The aim of this study is to present the criteria for the diagnosis of incomplete or partial block within the anterior and posterior divisions of the left bundle-branch (LBB). To disclose incomplete left anterior hemiblock (LAH) and incomplete left posterior hemiblock (LPH), clinical cases of pathologic and physiologic intermittent or transient block in the divisions of the LBB are analyzed. When dealing with the diagnosis of incomplete LAH, an ÂQRS shift in the same or in successive tracings in a patient, showing electrical axis at +50°, +40°, +30°, and 0° covering the whole range up to -45° or even more negative, makes the diagnosis of incomplete to complete block in the anterior division of the LBB.

Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias.

Background: Tolvaptan, a nonpeptide selective vasopressin receptor (V2) antagonist, is in development for the treatment of congestive heart failure and hyponatremia. Tolvaptan is primarily metabolized via CYP3A4. This study was conducted to determine the extent of the pharmacokinetic interaction between tolvaptan and steady state amiodarone, an antiarrhythmic drug commonly prescribed for patients with congestive heart failure and a known inhibitor of other drugs metabolized by CYP3A4.