Publications by authors named "Marcelo Straesser Franco"
Angew Chem Int Ed Engl
August 2021
Article Synopsis
- The study presents a sustainable method for hydroxymethylation or methylenation of imidazo-heteroarenes using KIO and formaldehyde generated from renewable sources like ethylene glycol and glycerol.
- This one-pot reaction yielded various 3-hydroxymethyl-imidazo-heteroarenes, important for pharmaceutical development, exemplified by Zolpidem.
- Additionally, the method allowed for the selective production of bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives with good to excellent yields using glycerol.
